Registration Dossier
Registration Dossier
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EC number: 241-866-1 | CAS number: 17927-72-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- other: study report
- Title:
- Initial submission to US EPA Summary of acute oral toxicity bis(pentane-2,4-dionato-O,O')bis(propan-2-olato)titanium
- Author:
- US EPA
- Year:
- 2 002
- Bibliographic source:
- US EPA
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Oral acute toxicity details in rats.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Bis(pentane-2,4-dionato-O,O')bis(propan-2-olato)titanium
- EC Number:
- 241-866-1
- EC Name:
- Bis(pentane-2,4-dionato-O,O')bis(propan-2-olato)titanium
- Cas Number:
- 17927-72-9
- Molecular formula:
- C16H28O6Ti
- IUPAC Name:
- bis(pentane-2,4-dionato-O,O')bis(propan-2-olato)titanium
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No other details available
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- No other details available
- Doses:
- Doses ranging from 1000 to 11 ,000 mg/kg of body weight.
- No. of animals per sex per dose:
- one rat per dose level
- Control animals:
- not specified
- Details on study design:
- The rats were observed for clinical signs of toxicity on the day of dosing and over a 14-day observation period.
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: non toxic
- Mortality:
- Death occurred in rats dosed at 5000, 7500, and 11000 mglkg of body weight within 18 hours after dosing.
- Clinical signs:
- other: The rats were observed for clinical signs of toxicity on the day of dosing and over a 14-day observation period.Clinical signs observed in the rats that died induded irregular respiration, gasping, prostration, weakness. and/or incoordination.
- Gross pathology:
- An rats that were found dead or sacrificed by design at the end of the observation peried were given a gross patholcgical examination.
Gross pattlological exarnination reveaied kidney tubules injury and/or pulmonary congestion.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 value in rat of bis(pentane-2,4-dionato-O,O')bis(propan-2-olato)titanium is assesed to be 5000 mg/kg bw.
- Executive summary:
Based on the clinical signs and toxicity the LD50 value in rat of bis(pentane-2,4-dionato-O,O')bis(propan-2-olato)titanium is assesed to be 5000 mg/kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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