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EC number: 248-654-8
CAS number: 27776-01-8
A study was performed to determine the acute oral median lethal dose
(LD50) of the test material, administered undiluted, in the
Sprague-Dawley strain rat. The method used followed that described in
the OECD Guidelines for Testing of Chemicals (1981) No. 401 "Acute Oral
Toxicity" referenced as Method B1 in Annex V of EEC Commission Directive
84/449/EEC. Following a range-finding study, four groups, each of ten
fasted animals (five males and five females), were given a single oral
dose of undiluted test material at dose levels of 2324 to 5000 mg/kg
bodyweight. Deaths were noted one to four days after dosing. Common
signs of toxicity noted were hunched posture and pilo-erection.
Additional or isolated incidents of toxicity noted were ataxia,
lethargy, red/brown stains around the snout, red/brown stains around the
mouth, pallor of the extremities, loss of righting reflex, decreased
respiratory rate, ptosis, increased salivation, dehydration and
diuresis. Surviving animals appeared normal throughout the study or
three or four days after dosing. Incidents of reduced bodyweight gain
were noted during the study. Abnormalities noted at necropsy of animals
that died during the study were haemorrhagic or abnormally red lungs,
dark or pale liver or patchy pallor of the liver, pale spleen, pale
kidneys, haemorrhage of the glandular and non-glandular gastric
epithelia and haemorrhage of the small and large intestines. No
abnormalities were noted at necropsy of animals killed at the end of the
study except for pale livers noted in two females treated with 2324
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