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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to microorganisms

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Administrative data

Link to relevant study record(s)

Description of key information

Available information:
The respiration rate of an activated sludge exposed to 1,1-DPE and fed with a standard amount of synthetic sewage feed was measured.. The inhibitory effect of the test substance was expressed as a percentage of the mean respiration rates of two controls. For a respiration inhibition test to be considered valid, the control values should be within 30% of each other. An EC50 obtained for the reference material must be within 2-25 mg/L. The control coefficient variation was 24% and an EC50 value of 9.19 mgIL was determined for the reference substance, rendering the test valid. For test substance 1-Phenylethylbenzene, an EC50 of> 1 000 mg/L was obtained at 3 hours post dose. Results presented are based on nominal concentrations.
The influence of Phenyl-tolyl-ethane on the respiration rate of activated sludge was investigated after a contact time of 3 hours according to OECD guideline 209. The EC50 was above the highest loading rate tested (1000 mg/l).

Key value for chemical safety assessment

EC50 for microorganisms:
1 000 mg/L

Additional information

From the available data for toxicity to microorganism generated from members of the diphenylmethane category it can be concluded by read-across that also Benzyltoluene is devoid of any relevant toxicity to microorganisms.

The key studies from the read-across substances PTE and 1,1 -DPE are GLP-compliant and have a Klimisch score of 1. The key studies are used for chemical safety assessment. The measured value for EC50 of >1000 mg/l is read across to Benzyltoluene. No further testing is required. For detailed read across rationale and justification see section 13, Read across document.