Registration Dossier
Registration Dossier
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EC number: 210-157-9 | CAS number: 608-27-5
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 8.01.1992-29.01.1992
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- 2,3-dichloroaniline
- EC Number:
- 210-157-9
- EC Name:
- 2,3-dichloroaniline
- Cas Number:
- 608-27-5
- Molecular formula:
- C6H5Cl2N
- IUPAC Name:
- 2,3-dichloroaniline
- Reference substance name:
- 2,3-dichlorobenzene
- IUPAC Name:
- 2,3-dichlorobenzene
- Details on test material:
- - Name of test material (as cited in study report): 2.3-dichloroaniline
- Physical state: solid
- Analytical purity: 99.5 %
- Impurities (identity and concentrations): 0.02% 3.chloraniline, 0.14% 3,4-dichloraniline, 0.29% unknown substances
- Storage condition of test material: Room temperature/in the dark
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose/head only
- Vehicle:
- other: air
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 0, 809, 8047 mg/m³ and air control
- No. of animals per sex per dose:
- 10
- Control animals:
- yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 8 047 mg/m³ air
- Exp. duration:
- 4 h
Any other information on results incl. tables
no mortality
clinical signs at 8047 mg/m³ in males and females:
-unspecific signs: rough and unkempt fur, reduced motility, staggering gait, tremor, atony, coma, body weight loss
-some animals with slight cyanosis
-and clinical signs indicative for respiratory irritational effects
labored breathing, bradypnoe, dyspnoe, breathing sounds, nasal discharge, bloody nose, hypothermia
NOEL:809 mg/m³
On day 9 post exposure all animals had recovered
Applicant's summary and conclusion
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