Registration Dossier
Registration Dossier
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EC number: 210-157-9 | CAS number: 608-27-5
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: data are shown only partly, description of the results only limited
Data source
Reference
- Title:
- No information
- Author:
- Lo H-H. et al. (1990). Acute nephrotoxicity induced by isomeric dichloroanilines in Fisher 344 rats. Toxicology 63, 215-231
Materials and methods
- Principles of method if other than guideline:
- Method: other: single i.p. inj. to 4-8 rats and renal function was noted 24 and 48 hrs later, clin. chem. and histopathol. examin., pair-fed controls, statistics: ANOVA and/or Student's t-test
- GLP compliance:
- not specified
- Type of method:
- in vivo
Test material
- Reference substance name:
- 2,3-dichloroaniline
- EC Number:
- 210-157-9
- EC Name:
- 2,3-dichloroaniline
- Cas Number:
- 608-27-5
- Molecular formula:
- C6H5Cl2N
- IUPAC Name:
- 2,3-dichloroaniline
- Details on test material:
- IUCLID4 Test substance: other TS: 2,3-dichloroaniline as hydrochloride, no data on purity
Constituent 1
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: 0.9 % saline
- No. of animals per sex per dose:
- Males 8
Results and discussion
Any other information on results incl. tables
mortality
1.0 mmol/kg bw-treatment group: 3/8
0.8 mmol/kg bw:
-on day 1: transient proteinuria (grade: +++ compared to control:+, data not shown)
-hematuria (grade: trace to +, data not shown)
-on day 2: significant increase in mean urine volume compaired to pair fed control: 19 ml versus 8 ml (graphic),
1.0 mmol/kg bw, day 1 (data from day 2 not shown)
-kidney weight decreased (0.35 g/100g bw versus 0.39g/100 g bw of pair fed control),
-basal and lactate-stimulated p-aminohipurate (PAH) accumulation decreased (Slice to Medium ratio [S/M ratio]: 3.8 versus 4.0 of pair fed control and 8.3 versus 10.8 of pair fed control)
-tetraethylamonium (TEA) was not reduced
-Mean blood urea nitrogen (BUN) concentration values were higher at 24 h (63.7 mg% versus 26 mg% at 0 h) than in the corresponding 48 h-treatment group (27 mg% versus 28 mg%)
Histopathological examination revealed moderate damaged proximal tubular segments of the nephron in the 0.8 and 1.0 mmol/kg bw treatment groups.
Applicant's summary and conclusion
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