Registration Dossier
Registration Dossier
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EC number: 217-031-2 | CAS number: 1724-39-6
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2 days
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to the United States Department of Transportation Regulations, Agent R.M. Grazziano's Tariff No. 25, April 24, 1972, p. 115, Section 173.343 for classification of chemical substances.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Dept of Transportation regulations, Agent R.M. Grazziano's Tariff No. 25, April 24, 1972, p. 115, scetion 173.343.
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- crude Cyclododecanol
- IUPAC Name:
- crude Cyclododecanol
- Details on test material:
- Test material is crude Cyclododecanol, cyclododecanol (84%), cyclododecanone (15%) and 1 % others (epoxide)
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: albino rabbits
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- The report states it followed the United States Department of Transportation Regulations, Agent R.M. Grazziano's Tariff No. 25, April 24, 1972, p. 115, Section 173.343 for classification of chemical substances method. There were six male albino rabbits.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- The undiluted test material was applied under 3" x 3"2 12-ply gauze pad to the clipped, intact dorsal skin of six male albino rabbits at a dose level of 200 mg/kg of body weight. The rabbits' trunks were then wrapped sucessively with Saran Wrap, Kling stretch gauze and Elastoplast adhesive tape. Plastic collars were applied before dosing.
- Duration of exposure:
- After 24-hours exposure period, the wrappings were removed. The animals were observed for 24-hours period before being sacrificed. This test is a total of 48 hours in duration.
- Doses:
- 200 mg/kg of body weight
- No. of animals per sex per dose:
- six male rabbits
- Control animals:
- not specified
- Details on study design:
- The undiluted test material was applied under 3" x 3"2 12-ply gauze pad to the clipped, intact dorsal skin of six male albino rabbits at a dose level of 200 mg/kg of body weight. The rabbits' trunks were then wrapped sucessively with Saran Wrap, Kling stretch gauze and Elastoplast adhesive tape. Plastic collars were applied before dosing.
- Statistics:
- NA.
Results and discussion
- Mortality:
- 0/6
- Clinical signs:
- other: all rabbits appeared normal for the duration of test.
- Gross pathology:
- NA
Any other information on results incl. tables
When tested and classified according to the regulations of the Department of Transportation , cyclododecanol and cyclododecanone mixture is not considered a Class B Poison by skin absorption.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: other: United States Department of Transportation Regulations, Agent R.M. Grazziano's Tariff No. 25, April 24, 1972, p. 115, Section 173.343 for classification of chemical substances method
- Conclusions:
- When tested and classified according to the regulations of the Department of Transportation , cyclododecanol and cyclododecanone mixture is not considered a Class B Poison by skin absorption.
- Executive summary:
There were six male albino rabbits. The undiluted test material (cyclododecanol (84%), cyclododecanone (15%) and 1 % others (epoxide)) was applied under 3" x 3"2 12-ply gauze pad to the clipped, intact dorsal skin of six male albino rabbits at a dose level of 200 mg/kg of body weight. The rabbits' trunks were then wrapped sucessively with Saran Wrap, Kling stretch gauze and Elastoplast adhesive tape. Plastic collars were applied before dosing. When tested and classified according to the regulations of the Department of Transportation , cyclododecanol and cyclododecanone mixture is not considered a Class B Poison by skin absorption.
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