Fatty acids, C5-9, hexaesters with dipentaerythritol

Endpoint summary

Additional information

There are no data available on the acute aquatic toxicity of carboxylic acids, C5-9, hexaesters with dipentaerythritol (CAS 67762-52-1). In order to fulfil the standard information requirements set out in Annex VII - IX, in accordance with Annex XI, 1.5, of Regulation (EC) No 1907/2006, read-across from one structurally related substance was conducted.

In accordance with Article 13 (1) of Regulation (EC) No 1907/2006, "information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI are met.” In particular for human toxicity, information shall be generated whenever possible by means other than vertebrate animal tests, which includes the use of information from structurally related substances (grouping or read-across).

Having regard to the general rules for grouping of substances and read-across approach laid down in Annex XI, Item 1.5, of Regulation (EC) No 1907/2006 whereby substances may be predicted as similar provided that their physicochemical, toxicological and ecotoxicological properties are likely to be similar or follow a regular pattern as a result of structural similarity.

Ecotoxicological parameters for the aquatic toxicity of the target substance carboxylic acids, C5-9, hexaesters with dipentaerythritol (CAS 67762-52-1) and the source substances are presented in the following table.

	Target	Source 1	Source 2	Source 3
CAS	67762-52-1	647028-25-9	84418-63-3	70983-72-1
Chemical Name	Carboxylic acids, C5-9, hexaesters with dipentaerythritol	Dipentaerythritol with fatty acids, C5 and C9iso	Isononanoic acid, mixed esters with dipentaerythritol, heptanoic acid and pentaerythritol	Fatty acids C5-10 esters with dipentaerythritol
MW	759-1095	983-1096	1095.61	759-1179
Fatty acid chain length	C5-9	C5,9iso	C9iso	C7-10
Alcohol	dipentaerythritol	dipentaerythritol	dipentaerythritol	dipentaerythritol
Short-term toxicity to fish	RA: CAS 647028-25-9 RA: CAS 84418-63-3	LL50 > 100 mg/L	LC50 > 1000 mg/L	--
Long-term toxicity to fish	Waiving based on Chemical Safety Assessment	--	--	--
Short-term toxicity to aquatic invertebrates	RA: CAS 70983-72-1 RA: CAS 647028-25-9	EL50 > 100mg/L	--	EL50 (48 h) > 1060 mg/L EL50 (48 h) = 78 mg/L
Long-term toxicity to aquatic invertebrates	NOEC (21d) ≥ 100 mg/L	--	--	--
Toxicity to aquatic algae	RA: CAS 647028-25-9	EL50 > 100 mg/L	--	--
Toxicity to microorganisms	RA: CAS647028-25-9 RA: CAS 84418-63-3	EC50 > 1000 mg/L	EL10 > 50 mg/L	--

 

The above mentioned substances are considered to be similar on the basis of the structural similarity resulting in properties and/or activities. The available endpoint information is used to predict the same endpoints for carboxylic acids, C5-9, hexaesters with dipentaerythritol.

A detailed analogue approach justification is provided in the technical dossier (see IUCLID section 13).

In accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5, grouping and read-across, the target substance carboxylic acids, C5-9, hexaesters with dipentaerythritol (CAS 67762-52-1) and the source substances dipentaerythritol with fatty acids, C5 and C9iso (CAS 647028-25-9), Isononanoic acid, mixed esters with dipentaerythritol, heptanoic acid and pentaerythritol (CAS 84418-63-3) and Fatty acids C5-10 esters with dipentaerythritol (CAS 70983-72-1) are not considered to be harmful to aquatic organisms based on the results from short-term studies with fish, aquatic invertebrates and algae.

All substances are structurally similar characterised by thesame alcohol component (dipentaerythritol) and similar fatty acid chain lengths, respectively.

Based on the structural, physico-chemical and ecotoxicological similarities, reading across between target and source substances is justified. As it can be seen in the data matrix including all relevant available ecotoxicological data, none of the substances lie out of the ecotoxicological profile, showing a consistent pattern of results.

Two acute toxicity studies to fish according to internationally accepted guidelines for the source substances dipentaerythritol with fatty acids, C5 and C9iso (CAS 647028-25-9) and isononanoic acid, mixed esters with dipentaerythritol, heptanoic acid and pentaerythritol (CAS 84418-63-3) are available.Both source substances and the target substance consist of the same alcohol component (dipentaerythritol) and similar fatty acid chain lengths (C5-9 for the target substance compared to C5,9iso and C9iso for the source substances, respectively).No effects were observed up to the limit of water solubility.

 

According to the “Guidance on information requirements and chemical safety assessment Chapter R.7b: Endpoint specific guidance, R.7.8.5.3” (ECHA, 2012), long-term testing of fish should only be conducted if it represents the most sensitive taxonomic group. The Guidance states that if invertebrates are likely to be more sensitive than fish and algae or the relative sensitivity of invertebrates cannot be predicted, long-term testing on Daphnia sp. should be preferred instead of fish. Therefore, no long-term testing on fish is proposed.

Two studies investigating the short-term toxicity to aquatic invertebrates for the source substances dipentaerythritol with fatty acids, C5 and C9iso (CAS 647028-25-9) and fatty acids C5-10 esters with dipentaerythritol (CAS 70983-72-1) are available.Both substances consist of the same alcohol component (dipentaerythritol) and similar fatty acid chain lengths (C5-9 for the target substance compared to C5,9iso and C7-10 for the source substances, respectively).No effects were observed up to the limit of water solubility.

A study investigating the long-term toxicity of target substance carboxylic acids, C5-9, hexaesters with dipentaerythritol (CAS 67762-52-1) to Daphnia magna demonstrated no detrimental effects of the substance on the survival and reproduction rate of D. magna. Thus, chronic effects of the target substance are not expected.

One study with algae is available for the source substance dipentaerythritol with fatty acids, C5 and C9iso (CAS 647028-25-9). The substance consists of the same alcohol component (dipentaerythritol) and similar fatty acid chain lengths as the target substance (C5-9 for the target substance compared to C5,9iso for the source substance). No effects were observed up to the limit of water solubility.

Two studies investigating the toxicity to microorganism in a read across approach with the structurally similar source substances dipentaerythritol with fatty acids, C5 and C9iso (CAS 647028-25-9) and isononanoic acid, mixed esters with dipentaerythritol, heptanoic acid and pentaerythritol (CAS 84418-63-3) was conducted. Both source substances and the target substance consist of the same alcohol component (dipentaerythritol) and similar fatty acid chain lengths as the target substance (C5-9 for the target substance compared to C9iso and C5,9iso for the source substances, respectively). Based on the results and the structural and profile similarity of the substances, it can be concluded that no effect on the STP microorganism community and the subsequent degradation process in sewage treatment plants is anticipated for any of the substances.

In conclusion, no acute or chronic effects on aquatic organisms were observed in the available studies for any of the three trophic levels (fish, daphnia, algae) up to the limit of water solubility.

The available data from suitable source substances allow for an accurate assessment of the ecotoxicity profile of the target substance carboxylic acids, C5-9, hexaesters with dipentaerythritol.