Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Partition coefficient

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
23 January to 21 March 2007
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Remarks:
The study was conducted according to an internationally recognised method, and under GLP. The substance is adequately identified, but some data on composition is missing. Therefore validation applies with restrictions.
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient - Shake Flask Method)
Deviations:
no
Principles of method if other than guideline:
Not applicable
GLP compliance:
yes (incl. QA statement)
Remarks:
24 February 2006
Type of method:
flask method
Partition coefficient type:
octanol-water
Analytical method:
gas chromatography
Key result
Type:
log Pow
Partition coefficient:
3.75
Temp.:
20 °C
pH:
ca. 0 - ca. 14
Details on results:
40 mL of pre-saturated water and 4 mL of pre-saturated n-octanol were mixed with 0.4 mL of a 10 g/L stock solution. The tubes were continuously rotated for 15 min and then centrifuged for 10 min at 5000 tr/min and 20 °C.
The test was reproduced using twice and half (2 replicates each) the above volume ratio.
Ratio 1:10-LogPow = 3.68 and 3.76
Ratio 1:20 - LogPow = 3.73 and 3.91
Ratio 2:10 - LogPow = 3.72 and 3.73
Mean Log Pow and observed interval = 3.75 [3.68 - 3.91].
The validity criteria were fulfilled: The six LogPow values fell within a range of ± 0.3 units.
ratio ratio 1:10 ratio 2:10 ratio 1:20
replicate vessel 1 2 1 2 1 2
log Kow 3,68 3,76 3,73 3,72 3,73 3,91
mass balance 95,3% 98,4% 98,7% 97,7% 102,9% 97,7%

Mean log Pow and SD = 3.75 +/-0.08

The observed interval within the six log Pow values was [3.68 - 3.91] and the validity criteria was fulfilled (< +/-0.3 unit).

The pH of the water phase was not measured.

Conclusions:
The substance has low potential to bioaccumulate in the environment, according to CLP classification criteria for aquatic chronic toxicity (log Kow <4).
Executive summary:

The partition coefficient of the test substance was determined under GLP according to EU A.8 guideline, flask method.

Determinations were conducted in duplicate for three solvents ratio, concentrations were measured using a GC-FID validated method. Individual results fulfilled the validity criteria for reproducibility, and mass balance was satisfactory, so the average value is retained.

The log Kow has been determined to be 3.75 at 20°C.

Description of key information

The data is relevant for classification in aquatic chronic toxicity hazard class, according to CLP criteria.

The substance has low potential for bioaccumulation (log Kow<4).

Key value for chemical safety assessment

Log Kow (Log Pow):
3.75
at the temperature of:
20 °C

Additional information

A reliable experimental study, conducted according to a recognized EC method and under GLP, is available. Despite restrictions due to incomplete test item identification it is considered as key study, and the result is retained as key data.