Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Dissociation constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- dissociation constant
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- key study
- Study period:
- 1999-06-23
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 112 (Dissociation Constants in Water)
- Version / remarks:
- adopted May 12 1981
- Deviations:
- not specified
- GLP compliance:
- yes
- Dissociating properties:
- no
- Remarks:
- does not dissociate in water
- Remarks on result:
- other: Based on Perrin's calculation method, the five organic esters in the test material have no Ka value(s).
- Conclusions:
- Based on Perrin's calculation method, the five organic esters in the test material have no Ka value(s). In conclusion, Santicizer® 2148 plasticizer does not dissociate in water.
- Executive summary:
A key OECD Guideline 112 study was conducted to determine the dissociation constant (Ka) of the test material (Santicizer® 2148) in water using the titration or spectrophotometric method. However, because of the low water solubility of the test material (as provided by the sponsor), both the titration and spectrophotometric methods were not applicable and hence the calculation method was used to determine the dissociation constant in water.
Based on Perrin's calculation method, the five organic esters in the test material have no Ka value(s). In conclusion, Santicizer® 2148 plasticizer does not dissociate in water.
Reference
Description of key information
Santicizer® 2148 plasticizer does not dissociate in water.
Key value for chemical safety assessment
Additional information
A key OECD Guideline 112 study was conducted to determine the dissociation constant (Ka) of the test material (Santicizer® 2148) in water using the titration or spectrophotometric method (NOTOX B.V, 1999h). However, because of the low water solubility of the test material (as provided by the sponsor), both the titration and spectrophotometric methods were not applicable and hence the calculation method was used to determine the dissociation constant in water.
Based on Perrin's calculation method, the five organic esters in the test material have no Ka value(s). In conclusion, Santicizer® 2148 plasticizer does not dissociate in water.
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