Registration Dossier
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EC number: 213-697-3 | CAS number: 1003-03-8
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Cyclopentylamine is not readily but inherently biodegradable after adaptation.
Key value for chemical safety assessment
Additional information
The assessment of the biodegradability of cyclopentylamine is based on a weight-of-evidence approach.
Several QSAR models predict cyclopentylamine to be not readily biodegradable, but the substance was not within the applicability domains of the different models due to structural issues:
- VEGA RBM v1.0.6 estimated the substance to be not readily biodegradable (BASF SE, 2013)
- CATALOGIC CO2 Kinetic (OECD 301B) v.01.03 calculated a biodegradation of 17.75% after 28d based on CO2 evolution (BASF SE, 2013)
- CATALOGIC BOD Kinetic (OECD 301F) v.08.09 estimated a biodegradation od 28.51% after 28d based on BOD (BASF SE, 2013).
The estimation model BIOWIN v.4.10 of EPI Suite v.4.10 predicts cyclopentylamine to be readily biodegradable in all models BIOWIN 1 to 6 (BASF SE, 2013). The substance is within the applicability domain of the estimation model. The model CATALOGIC MITI (OECD 301C) v.06.07 predicts 0% biodegradation based on O2 consumption (BASF SE, 2013). The substance is 100% in the parameter, structural and mechanistic domains.
One inherent biodegradation test following Zahn-Wellens method determined cyclopentylamine to be inherently biodegradable based on a DOC removal of 96% after 24d (BASF AG, 1988). The activated sludge used for the test was taken from an industrial wwtp. Consequently, it can be concluded that the inoculum has already been adapted to the substance.
In conclusion, four models predict the substance to be not readily biodegradable, one model estimated cyclopentylamine to be readily biodegradable. A Zahn-Wellens test determined the substance to be inherently biodegradable with industrial activated sludge. Therefore, cyclopentylamine is supposed to be not readily but inherently biodegradable after adaptation.
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