Registration Dossier
Registration Dossier
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EC number: 411-950-4 | CAS number: 96562-58-2 DHPPME; MAK-ME; MEHPOPS; R-MAQ-ME
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Under the conditions of this study, the 96 hour LC50 value was determined to be 94 mg/L with 95 % confidence limits of 78 to 100 mg/L. The 96 hour NOEC value was 53 mg/L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 94 mg/L
Additional information
The acute toxicity of the test material to Oncorhynchus mykiss was assessed in a study which was conducted in accordance with the standardised guidelines OECD 203 and EU Method C.1 under GLP conditions. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).
The study was conducted under semi static conditions. Fish were exposed to the test material at nominal concentrations of 18, 32, 56, 100, 180 and 320 mg/L (10 fish per dose level). Measured test concentrations were 18, 31, 53, 95, 160 and 300 mg/L (mean of fresh and expired media sampled at 0 and 24 hours and, where appropriate, 72 and 96 hours). Observations were made on the numbers of dead fish and the incidence of sub-lethal effects after 3, 6, 24, 48, 72 and 96 hours of exposure. All results are expressed in terms of measured concentrations.
The cumulative mortality at 96 h was 4, 10 and 10 fish at the 100, 180 and 320 mg/L dose levels, respectively. Marked reactions to exposure (other than death) were increased pigmentation, loss of equilibrium, lethargy and hanging vertically in the water column.
Under the conditions of this study, the 96 hour LC50 value was determined to be 94 mg/L with 95 % confidence limits of 78 to 100 mg/L. The 96 hour NOEC value was 53 mg/L.
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