Methyl (R)-2-(4-hydroxyphenoxy)propionate

Vapour pressure

Description of key information

Campbell et al. (1993): Under the conditions of the study, the vapour pressure was determined to be <9 x 10^-6 Pa, at 20 °C and 30 °C.

Brunner (1991): Under the conditions of the study, the vapour pressure of the test material was determined to be 0.5 and 20 mPa at 20 and 50 °C, respectively.

Key value for chemical safety assessment

Vapour pressure:

0 Pa

at the temperature of:

20 °C

Additional information

Two studies are available to address this endpoint and both are considered to be key as the data are equally reliable. The studies were assigned a reliability score of 1 in accordance with the criteria for assessing data quality set forth by Klimisch et al. (1997).

Campbell et al. (1993)

The vapour pressure of the test material was investigated in accordance with the standardised guidelines OECD 104 and EU method A.4 under GLP conditions using the gas saturation method.

The test material was coated onto small glass beads which were placed in three saturator columns. Nitrogen was passed through at flow rates of 15 and 5 cm3/min for a total of >320 h. The saturator columns were each connected in series with an absorber trap, which contained acetonitrile, and an oil trap. The flow rate was monitored and adjusted as required over the period of the experiment. On completion of the test the trapping solvent was removed under a gentle stream of nitrogen and the residue was reconstituted in 1 mL of internal standard solution, and chromatographed. The test was conducted at 20 ± 1 °C and 30 ± 1 °C.

The test material was not detected in any of the samples from either of the test temperatures of 20 or 30 °C. Hence all calculations were performed using the limit of detection of 0.2 µg/mL.

The individually calculated average values were: <8.2 x 10^-6 for the 20 °C test and <8.9 x 10^-6 Pa for the 30 °C test. 

Under the conditions of the study, the vapour pressure was determined to be <9 x 10^-6 Pa, at 20 °C and 30 °C.

Brunner (1991)

The vapour pressure of the test material was investigated in accordance with the standardised guideline EU Method A.4 under GLP conditions using the dynamic method.

Comparison of the measurement of the vapour pressure with the vapour pressures of the n-alkanes shows that over the range of temperature examined the vapour pressure of the test material agrees to a first approximation with the vapour pressure of heneicosane.

Extrapolation of the above experimental data to lower temperatures, carried out parallel to the vapour pressure of heneicosane, gave approximate values of 0.5 mPa at 20 °C and 20 mPa at 50 °C.

Under the conditions of the study, the vapour pressure of the test material was determined to be 0.5 and 20 mPa at 20 and 50 °C, respectively.