Octan-1-ol, ethoxylated

Water solubility

Administrative data

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

6 Dec 2018 - 6 Feb 2019

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2019

Report date:

2019

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Test guideline 2

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

GLP compliance:

no

Remarks:

study conducted in a facility which operates in accordance with Good Laboratory Practice principles; however, no claim of GLP compliance was intended nor is made for this study

Type of method:

flask method

Test material

Test material information

Constituent 1

Reference substance name:

Octan-1-ol, ethoxylated

EC Number:

500-058-1

EC Name:

Octan-1-ol, ethoxylated

Cas Number:

27252-75-1

Molecular formula:

C10H22O2

IUPAC Name:

Octan-1-ol, ethoxylated

Test material form:

liquid

Results and discussion

Water solubility

Water solubility:

1.85 g/L

Temp.:

20 °C

pH:

>= 3.6 - <= 3.7

Any other information on results incl. tables

The preliminary estimate of the water solubility at 20.0 ± 0.5 °C was 1.73 g/L. The solution had a pH of 4.9.

The mean peak areas relating to the standard and sample solutions are listed in the following table:

Solution	Mean Peak Area
Standard 213 mg/L	1.8202E+07
Standard 203 mg/L	1.7174E+07
Matrix blank	not detected
Sample 1A	7.6084E+06
Sample 1B	7.6787E+06
Sample 2A	7.7331E+06
Sample 2B	7.7943E+06
Sample 3A	7.9699E+06
Sample 3B	8.3636E+06

The concentration (g/L) of test item in the sample solutions is given in the following table:

Sample no.	Time shaken at 30 °C (hrs)	Concentration (g/L)	Solution pH
1	24	1.80	3.7
2	48	1.83	3.7
3	72	1.92	3.6

Mean concentration: 1.85 g/L at 20.0 ± 0.5 ºC, pH 3.6 -3.7

Validation:

The linearity of the detector response with respect to concentration was assessed over the nominal concentration range of 25 to 250 mg/L. The results were satisfactory with a correlation coefficient (r) of 0.9996 being obtained.

Discussion:

On completion of the equilibration period, the samples were clear and colorless with excess test item present on the surface. After centrifugation and filtration, the solutions were visually observed to be clear, colorless but with a Tyndall beam effect.

As the water solubility was determined during the preliminary test to be above 10E-02 g/L, the flask shaking test was performed.

All individual water solubility results were within ± 15% of the mean, thus satisfying the criteria specified in the guidelines.

As the test item is multi-component, the results represent the test item as whole.