Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP. Guideline study

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed
Year:
2011
Report date:
2011

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 111 (Hydrolysis as a Function of pH)
Qualifier:
according to guideline
Guideline:
EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
Ethyl [(4-methylphenyl)sulphonyl]carbamate
EC Number:
226-952-9
EC Name:
Ethyl [(4-methylphenyl)sulphonyl]carbamate
Cas Number:
5577-13-9
Molecular formula:
C10H13NO4S
IUPAC Name:
ethyl [(4-methylphenyl)sulfonyl]carbamate
Radiolabelling:
not specified

Study design

Analytical monitoring:
not specified
Duration of test
Duration:
5 d

Results and discussion

Transformation products:
not measured
Remarks:
Research to investigate the identity or nature and rates of formation and decline of hydrolysis products was not required since the studies were conducted according to the EU testing guidelines provided in Annex VII and VIII (volume 10-100 tons/year).
Details on hydrolysis and appearance of transformation product(s):
Research to investigate the identity or nature and rates of formation and decline of hydrolysis products
was not required since the studies were conducted according to the EU testing guidelines provided in
Annex VII and VIII (volume 10-100 tons/year).
Dissipation DT50 of parent compoundopen allclose all
Key result
pH:
4
Temp.:
20 °C
DT50:
ca. 2.2 yr
Key result
pH:
4
Temp.:
25 °C
DT50:
ca. 309 d
Key result
pH:
4
Temp.:
50 °C
DT50:
ca. 3.8 d
Key result
pH:
4
Temp.:
60 °C
DT50:
ca. 23 h
Key result
pH:
7
Temp.:
25 °C
DT50:
> 1 yr
Key result
pH:
9
Temp.:
25 °C
DT50:
> 1 yr

Any other information on results incl. tables

Hydrolysis at pH 4: t1/2 (20ºC)= 2,2 years

t1/2 (25ºC)= 309 days ;

t1/2 (50ºC)= 3,8 days;

t1/2 (60ºC)= 23 hours.

Hydrolysis at pH 7: t1/2 (25ºC)> 1 year

Hydrolysis at pH 9: t1/2 (25ºC)> 1 year

Applicant's summary and conclusion

Conclusions:
The preliminary test and main study were performed for the determination of the rate of hydrolysis of Tolfamato at pH values normally found in the environment (pH 4-9).