Registration Dossier
Registration Dossier
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EC number: 226-952-9 | CAS number: 5577-13-9
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP. Guideline study
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Remarks:
- HPLC method at pH 2 and neutral pH
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- Ethyl [(4-methylphenyl)sulphonyl]carbamate
- EC Number:
- 226-952-9
- EC Name:
- Ethyl [(4-methylphenyl)sulphonyl]carbamate
- Cas Number:
- 5577-13-9
- Molecular formula:
- C10H13NO4S
- IUPAC Name:
- ethyl [(4-methylphenyl)sulfonyl]carbamate
Constituent 1
Results and discussion
Partition coefficientopen allclose all
- Type:
- log Pow
- Partition coefficient:
- 0.73
- Temp.:
- 23 °C
- pH:
- 7
- Remarks on result:
- other: pH neutral
- Type:
- Pow
- Partition coefficient:
- 5.3
- Temp.:
- 23 °C
- pH:
- 7
- Remarks on result:
- other: pH neutral
- Type:
- log Pow
- Partition coefficient:
- 1.7
- Temp.:
- 23 °C
- pH:
- 2
- Type:
- Pow
- Partition coefficient:
- 55
- Temp.:
- 23 °C
- pH:
- 2
Applicant's summary and conclusion
- Conclusions:
- The HPLC method at neutral pH and at pH 2 was applied for the determination of the partition coefficient (Pow) of Tolfamato.
The Pow and log Pow value of the test substance at neutral pH and at pH 2 was:
Pow (neutral pH): 5.3 ; log Pow (neutral pH): 0.73
Pow (pH 2): 55 ; log Pow (pH 2): 1.7
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