Registration Dossier
Registration Dossier
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EC number: 202-873-5 | CAS number: 100-63-0
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
Non-human data:
Data on the skin sensitization potential of phenylhydrazine was available. A 10 % solution of phenylhydrazine in alcohol was painted on a skin site that had been pretreated 2–3 weeks previously with undiluted phenylhydrazine (Jadassohn, 1930). Very intense erythema and swelling, followed by scaling and encrustation, were consistently seen.
Human data:
There are a number of case reports of skin hypersensitivity reactions to phenylhydrazine and its hydrochloride salt in humans. Solomons (1946) conducted a patch test in one subject with a phenylhydrazine crystal placed on the forearm under a dressing. Marked erythema and some oedema developed on the exposure site after 18 h, with the formation of vesicles after 30 h and crusting after a further 24 h. Similar hypersensitive skin reactions were reported following individual exposures to solid or aqueous solutions of phenylhydrazine or phenylhydrazine salts (Wright & Joyner, 1930; Frost & Hjorth, 1959; Pevny & Peter, 1983). There is also evidence that cross-sensitization can occur between hydrazine compounds, so that subjects already sensitized to hydrazine, a known skin sensitizer, are also sensitized to hydrazine derivatives, including phenylhydrazine (Malten, 1962; Van Ketel, 1964; Hovding, 1967; Rothe, 1988).
No data are available on the potential of phenylhydrazine to cause respiratory tract sensitization.
Migrated from Short description of key information:
Phenylhydrazine was considered a skin sensitizer.
Respiratory sensitisation
Endpoint conclusion
- Additional information:
- Migrated from Short description of key information:
No information was available for respiratory tract sensitization.
Justification for classification or non-classification
Based on results available, phenylhydrazine was classified and labelled as skin sensitizer R, 43 according to Directive 67/548/EEC (DSD) and as skin sensitizer cat. 1 (H317) according to Regulation 1272/2008/EC (CLP).
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