Registration Dossier
Registration Dossier
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EC number: 202-873-5 | CAS number: 100-63-0
Endpoint summary
Administrative data
Description of key information
Additional information
Three studies assessing the aquatic toxicity of phenylhydrazine were available:
In an acute toxicity study with goldfish (Carassius auratus), 40 % of fish died when exposed to phenylhydrazine at a nominal concentration of 1 mg/L for 48 h (Houston et al., 1988). Signs of toxicity included erratic swimming, sinking to the bottom of the test tank, and slowed and erratic respiration. No gross lesions were found following dissection, although all viscera showed focal haemorrhaging. Effects on blood cells and the haematopoietic system, comparable to those found in mammals, were seen in fish injected with phenylhydrazine.
In the early life stage test with newly fertilized eggs of the zebra fish , eggs were exposed to concentrations of phenylhydrazine through hatch and into the larval stage (total exposure time was 16 days) (Xiu et al., 1992). A NOEC (survival) was established for eggs at 5 days post-fertilization at 0.0039 mg/L, with a lowest-observed-effect concentration (LOEC) at 0.0078 mg/L. At the end of the test (16 days), the NOEC for larvae was 0.000 49 mg/L, and the LOEC was 0.000 98 mg/L.
After direct injection of 12.5 mg phenylhydrazine/kg body weight in Chinook salmon (Oncorhynchus tshawytscha) juveniles, red cell count, haemoglobin, and haematocrit fell to 1–5 % of their normal values within 10 days of treatment; a slight improvement was reported 15 days following injection, and values had returned to normal 95 days after treatment (Smith et al., 1971).
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