Phenylhydrazine

Endpoint summary

Additional information

Phenylhydrazine was assessed in several terrestrial toxicity studies:

In one growth inhibition test with fungi, phenylhydrazine at 21.6 mg/L in a nutrient culture medium had no effect on the growth of various species (Zsolnai, 1975).

In a seed germination study phenylhydrazine concentration of 50 mg/L in a hydroponic culture solution inhibited germination of Hordeum seeds for at least 6 days, whereas growth was stimulated in Lepidium. At 100 mg/L, seedling growth was stimulated in Hordeumbut not in Lepidium. At 500 mg/L, phenylhydrazine inhibited growth in seedlings of both species, although the seedlings were still apparently “healthy” (Bokorny, 1933).

Phenylhydrazine was assessed in two nematode studies. Exposure of soil nematodes Caenorhabditis briggsae in culture to phenylhydrazine at 50 mg/L of medium resulted in reduced growth of all four larval stages (the effect was most marked on the last larval instar) and therefore delayed development to adults. However, the adults formed were capable of reproduction, although the number of progeny was reduced. A concentration of 15 mg/L also delayed development, although to a lesser degree compared with the higher concentration (Kampfe et al., 1986).

In a second study with Caenorhabditis briggsae a 6-day EC50 of 12 mg/L was reported for production of progeny in culture (Kreil, 1982).

No dietary or oral toxicity studies were performed on birds. However, injection studies revealed haemolytic anaemia and reduced white cell counts in birds. In contrast to mammals, cell division in erythropoietic tissue was unaffected by phenylhydrazine (Williams, 1972; Clark et al., 1988; Datta et al., 1989, 1990).