Registration Dossier
Registration Dossier
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EC number: 202-873-5 | CAS number: 100-63-0
Endpoint summary
Administrative data
Description of key information
Phenylhydrazine was considered a skin and eye irritant.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Non-human data:
Skin irritation
In a single dose toxicity study with rabbits phenylhydrazine hydrochloride was applied to the skin for 24 h moistened with distilled water, under either an occlusive or semi-occlusive dressing, (Derelanko et al., 1987). Skin irritation was seen in all rabbits, with some necrosis at the treated site at 24 h post-application and sloughing of the skin reported in some animals.
In a skin irritation study with rats, signs of irritation appeared within 24 h and persisted for up to 7 days post-exposure. Necrosis developed in a small number of rats.
Eye irritation
In an eye irritation study with rabbits application of a 50 % solution of phenylhydrazine to the eyes of rabbits caused severe suppurative conjunctivitis (Pham, 1979).
Respiratory irritation
No data available.
There was no evidence of corrosive effects to skin or eyes.
Human data:
Skin irritation
Occupational exposure data on skin irritation was available, with several reports following accidental spillage. No irritancy effects were observed in workers exposed to liquid phenylhydrazine following accidental exposure (Schuckmann, 1969). Following dermal contact to phenylhydrazine hydrochloride powder skin irritation effects were reported in two cases. Local irritation, superficial erythema, and partly bullous-papular changes were noted in one case following spillage of powder on arms; multiple burn marks and small blisters at the site of contact were reported in the second case in which phenylhydrazine hydrochloride had spilled into the worker’s gloves and shoes. However, the severity of skin irritation effects may vary.
Eye irritation
No human data was available on the eye irritation potential of phenylhydrazine. There were no reports of corrosive effects from occupational use.
Respiratory irritation
There were no reports of respiratory irritation from occupational use.
Effects on skin irritation/corrosion: irritating
Effects on eye irritation: irritating
Justification for classification or non-classification
Skin:
Based on Directive 67/548/EC (DSD) and Regulation 1272/2008/EC (CLP), phenylhydrazine is classified as skin irritant (Xi, R36; cat 2, H315).
Eye:
Based on Directive 67/548/EC (DSD) and Regulation 1272/2008/EC (CLP), phenylhydrazine is classified as eye irritant (Xi, R38; cat 2, H319).
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