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REACH

Ethyl chloroformate

EC number: 208-778-5 | CAS number: 541-41-3

Life Cycle description
Uses advised against

Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Description of key information

Hydrolysis product ethanol: With high probability acutely not harmful to fish.
Hydrolysis product HCl: Acutely toxic to fish (pH dependent).

Key value for chemical safety assessment

Additional information

Parent compound: 96-h LC0 = 47 mg/L (Bayer AG, 1996). Ethyl chloroformate hydrolyses rapidly to ethanol, HCl and CO₂. Hydrolysis product ethanol: 96-h LC50 = 13000 / 14200 mg/L (OECD, 2005).

Hydrolysis product HCl: 96 -h LC₅₀ = 4.92 mg/L (OECD, 2002)

Species	Results	Remarks	Reference
Danio rerio	LC0 (96 h) = 47 mg/L (nominal); German Industrial Standard DIN 38412, part 15	reliability: 4	Bayer AG, 1996
Pimephales promelas	LC50 (96 h) = 14200 mg/L (nominal); flow-through; acute fish toxicity test	Hydrolysis product ethanol; reliability: 2, key study	OECD, 2005
Oncorhynchus mykiss	LC50 (96 h) = 13000 mg/L (nominal); static acute fish toxicity test	Hydrolysis product ethanol; reliability: 2, key study	OECD, 2005
Cyprinus carpio	LC₅₀(96 h) = 4.92 mg/L (acid equivalent to pH 4.3), semi-static, with analytical monitoring, OECD TG 203	Hydrolysis product HCl; reliability: 2, key study	OECD, 2002
Oncorhynchus mykiss	LC₅₀(96 h) = 7.45 mg/L (acid equivalent to pH 4.12), fish acute toxicity test	Hydrolysis product HCl; reliability: 2, supp. study	OECD, 2002

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