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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Three Repeat Dose Studies have been conducted on the source chemical n-butyl acrylate.  These results are considered to be appropriate for the target chemical 2-methylbutyl acrylate.
13 Week Drinking Water Study in Rats:  
NOAEL Males:  84/mg/kg (Highest Dose Tested); 
NOAEL Females:  111mg/kg (Highest Dose Tested)
13 Week Oral Gavage Study in Rats:
LOAEL Male/Female:  150 mg/kg (Only dose tested; increased relative liver weights only)
13 Week Inhalation Study in Rats
NOAEC Systemic Effects:  108 ppm 
LOAEC: Systemic Effects (body weight decrease, clinical chemistry changes in females only):  211 ppm
NOAEC Local: 21 ppm
LOAEC: Local (histological changes in nasal mucosa):  108 ppm

Key value for chemical safety assessment

Additional information

Three Repeat Dose Studies have been conducted on the source chemical n-butyl acrylate. These results are considered to be appropriate for the target chemical 2-methylbutyl acrylate.

 

In all three tests, systemic toxicity was low; some of the effects reported as adverse may not be considered adverse. Recovery data are not available so it is difficult to decide if the effects are adverse or adaptive. The results indicate that there is low risk for adverse systemic effects based on repeated exposures. Local effects such as those seen in the inhalation study are more relevant to repeat dose toxicity.

Data matrix – Analog approach

Target substance

Source substance (1)

 

CHEMICAL NAME

2-methylbutyl acrylate

n-butyl acrylate

 

CAS#

44914-03-6

141-32-2

 

Molecular formula

C8H14O2

C7H12O2

 

Molecular Weight

142.2

128.2

 

PHYSICO-CHEMICAL DATA     

Melting Point

Experimental:

≤ -75 °C

Not available

 

Boiling Point

Experimental:

161.7 °C at 1013hPa

Experimental:

147 °C at 1013hPa

 

Density

Experimental:

0.8886 g/cm3 at 25 °C

Experimental:

0.9 g/cm3 at 20.0 °C

 

Vapour Pressure

Experimental:

1.7 hPa at 20°C

Experimental:

5 hPa at 22.2°C

 

Partition Coefficient (log KOW)

Experimental:

2.9

Experimental:

2.38 (at 25°C)

 

Water Solubility

Experimental:

316 mg/L at 23 °C

Not available

 

MAMMALIAN TOXICITY

13 Week Drinking Water Study in rats

Readacross from source (1):

NOAEL Males:  84/mg/kg (Highest Dose Tested);

NOAEL Females:  111mg/kg (Highest Dose Tested)

Experimental:

NOAEL Males:  84/mg/kg (Highest Dose Tested);

NOAEL Females:  111mg/kg (Highest Dose Tested)

 

13 Week Oral Gavage study in rats

Readacross from source (1):

LOAEL Male/Female:  150 mg/kg (Only dose tested; increased relative liver weights only)

Experimental:

LOAEL Male/Female:  150 mg/kg (Only dose tested; increased relative liver weights only)

 

13 Week Inhalation Study in Rats

Readacross from source (1):

NOAEC Systemic Effects:  108 ppm

LOAEC: Systemic Effects (body weight decrease, clinical chemistry changes in females only):  211 ppm

NOAEC Local: 21 ppm

LOAEC: Local (histological changes in nasal mucosa):  108 ppm

Experimental:

NOAEC Systemic Effects:  108 ppm

LOAEC: Systemic Effects (body weight decrease, clinical chemistry changes in females only):  211 ppm

NOAEC Local: 21 ppm

LOAEC: Local (histological changes in nasal mucosa):  108 ppm

 

Justification for classification or non-classification

Results did not meet the criteria for classification.