Registration Dossier
Registration Dossier
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EC number: 256-170-3 | CAS number: 44914-03-6
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Read-across of data for an analogous chemical. The target chemical and the source chemical are very closely related alkyl acrylate compounds. They differ only by the addition of a methyl group in the butyl portion of the molecule. Both molecules are expected to be metabolized via the same hydrolysis and enzymatic pathways. The data from the source chemical are experimental results from well documented studies which meet basic scientific principles and are considered to be acceptable with restrictions.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Reference Type:
- secondary source
- Title:
- SIDS Initial Assessment Report for SIAM 15 (n-Butyl acrylate) October 22-25, 2002 Boston.
- Author:
- OECD SIDS
- Year:
- 2 002
- Bibliographic source:
- UNEP Publications
Materials and methods
- Principles of method if other than guideline:
- Male albino rabbits were applied with the undiluted test substance under impervious sheeting on the clipped intact skin of the trunk. The animals were immobilized during the 24-hour contact period. Thereafter, excess fluid was removed to prevent ingestion.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Butyl acrylate
- EC Number:
- 205-480-7
- EC Name:
- Butyl acrylate
- Cas Number:
- 141-32-2
- IUPAC Name:
- butyl acrylate
- Details on test material:
- - Name of test material (as cited in study report): Butyl acrylate
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- male
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 h
- Doses:
- no data
- No. of animals per sex per dose:
- The total number of animals was 12.
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2 000 mg/kg bw
- Clinical signs:
- other: Iritis occurred in the eyes during the 24 hour exposure period with butyl acrylate.
- Gross pathology:
- Livers were found to be mottled, with prominent acini; kidneys and spleens were congested in victims.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Executive summary:
The results presented in this summary are experimental results for the source chemical n-butyl acrylate. The results are considered to be appropriate for read-across to the target chemical 2-methylbutyl acrylate.
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