Registration Dossier
Registration Dossier
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EC number: 256-170-3 | CAS number: 44914-03-6
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Additional information:
The LLNA test resulted in an EC3 index of 11.2% and n-butyl acrylate is determined to be a skin sensitizer.
Data matrix – Analog approach
Target substance
Source substance (1)
CHEMICAL NAME
2-methylbutyl acrylate
n-butyl acrylate
CAS#
44914-03-6
141-32-2
Molecular formula
C8H14O2
C7H12O2
Molecular Weight
142.2
128.2
PHYSICO-CHEMICAL DATA
Melting Point
Experimental:
≤ -75 °C
Not available
Boiling Point
Experimental:
161.7 °C at 1013hPa
Experimental:
147 °C at 1013hPa
Density
Experimental:
0.8886 g/cm3 at 25 °C
Experimental:
0.9 g/cm3 at 20.0 °C
Vapour Pressure
Experimental:
1.7 hPa at 20°C
Experimental:
5 hPa at 22.2°C
Partition Coefficient (log KOW)
Experimental:
2.9
Experimental:
2.38 (at 25°C)
Water Solubility
Experimental:
316 mg/L at 23 °C
Not available
MAMMALIAN TOXICITY
Skin Sensitization
Readacross from source (1):
Weak sensitizer
Experimental:
Weak sensitizer
Migrated from Short description of key information:
A Mouse Local Lymph Node Assay was conducted on the source chemical n-butyl acrylate and is considered to be appropriate for the target chemical n-methylbutyl acrylate.
LLNA results in an EC3 of 11.2%
Respiratory sensitisation
Endpoint conclusion
- Additional information:
- Migrated from Short description of key information:
Results meet the EU DPD criteria for classification as a skin sensitizer.
Justification for classification or non-classification
Results meet the EU DSD and CLP criteria for classification as a skin sensitizer. 2-MBA is classified Xi R43 and as Skin Sens 1B.
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