Registration Dossier
Registration Dossier
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EC number: 902-591-9 | CAS number: -
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Investigation which cannot be subsumed undere a testing guideline, but which is well documented and scientifically acceptable.
Data source
Reference
- Reference Type:
- publication
- Title:
- Studio sulla stabilita degli esteri nel sangue in vitro
- Author:
- S. Ghittore, M. Imnriani, F. Borlini, G. Pezzagno, P. Zadra
- Year:
- 1 984
- Bibliographic source:
- Boll.. Soc. Ital. Biol. Sper. 60811), 2207 - 2213
Materials and methods
- Objective of study:
- metabolism
- Principles of method if other than guideline:
- Methyl acetate and other esters were adminstered by inhalation. Identification of methyl acetate and conversion products was by GC-MS.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Methyl acetate
- EC Number:
- 201-185-2
- EC Name:
- Methyl acetate
- Cas Number:
- 79-20-9
- Molecular formula:
- C3H6O2
- IUPAC Name:
- Methyl acetate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- other: blood
Administration / exposure
- Route of administration:
- inhalation
- Vehicle:
- unchanged (no vehicle)
Doses / concentrations
- Dose / conc.:
- 610 mg/m³ air
Results and discussion
- Preliminary studies:
- Hydrolysis of methyl acetate in blood at 37ºC was: concentration: 2.18 μg/L; 7 hours later: 1.96 μg/L.
The products were identified as acetic acid and methanol.
Applicant's summary and conclusion
- Conclusions:
- No bioaccumulation potential based on study results.
Methyl acetate in blood is hydrolysed by forming methanol and acetic acid. - Executive summary:
Methyl acetate in blood is hydrolysed by forming methanol and acetic acid.
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