Registration Dossier
Registration Dossier
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EC number: 902-591-9 | CAS number: -
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- For Read-Across Justification please refer to Section 13.
- Reason / purpose for cross-reference:
- read-across source
- Conc. based on:
- not specified
- Temp.:
- 20 °C
- Remarks on result:
- completely miscible
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Type of method:
- other: not specified
- Key result
- Conc. based on:
- not specified
- Temp.:
- 20 °C
- Remarks on result:
- completely miscible
- Remarks:
- no pH value reported
- Conclusions:
- The test item is completely miscible with water at 20 °C.
- Executive summary:
Value from generally accepted handbook data. The test item is completely miscible with water at 20 °C.
- Endpoint:
- water solubility
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- For Read-Across Justification please refer to Section 13.
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Water solubility:
- 240 g/L
- Temp.:
- 20 °C
- Remarks on result:
- other: no pH reported
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Type of method:
- other: not specified
- Key result
- Water solubility:
- 240 g/L
- Conc. based on:
- not specified
- Loading of aqueous phase:
- 0 mg/L
- Incubation duration:
- 0 min
- Temp.:
- 20 °C
- pH:
- 7 - < 8
- Remarks on result:
- other:
- Remarks:
- conc. based on, loading of aqueous phase, incubation duration and pH value not reported. For technical reasons dummy values are given.
- Key result
- Type of test:
- other: not measured
- Mean dissolved conc.:
- 0 mg/L
- Element analysed:
- none
- Loading of aqueous phase:
- 0 mg/L
- Incubation duration:
- 0 min
- Test conditions:
- none
- Remarks on result:
- not measured/tested
- Remarks:
- not measured
- Conclusions:
- The water solubility of the test item was determined to be 240 g/L at 20 °C.
- Executive summary:
Value from generally accepted handbook data. The water solubility of the test item was determined to be 240 g/L at 20 °C.
Referenceopen allclose all
The solubility in water at 20 °C is reported to be 24 % by weight. This corresponds to a water solubility of 240 g/L at 20 °C.
Description of key information
Following an analogue read-across approach the water solubility was determined to be 240 g/L at 20 °C.
Key value for chemical safety assessment
- Water solubility:
- 240 g/L
- at the temperature of:
- 20 °C
Additional information
The test item is a mixture of methanol and methyl acetate. No study was available for the water solubility of the mixture, but for the single components methanol and methyl acetate. Therefore, an analogue read-across approach was used.
Methanol is reported to be completely soluble in water at 20 °C.
The water solubility of methyl acetate is reported to be 240 g/L at 20 °C.
Both values are taken from peer reviewed handbooks and so can be considered as reliable. Based on an analogue read-across approach the lowest water solubility of the two components was regarded as worst case. Consequently, a water solubility of 240 g/L at 20 °C was chosen as key value for further chemical safety assessment purposes.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
