Reaction mass of methyl acetate and methanol

Direct observations: clinical cases, poisoning incidents and other

Administrative data

Endpoint:

direct observations: clinical cases, poisoning incidents and other

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Reliability:

other: Read-across, see cross-reference

Justification for type of information:

Please refer to IUCLID section 13 for Read Across Justification.

Materials and methods

Test material

Test material information

Constituent 1

Reference substance name:

methanol; methyl acetate

EC Number:

902-591-9

Molecular formula:

not applicable

IUPAC Name:

methanol; methyl acetate

Results and discussion

Results of examinations:

A three month follow-up examination showed no change in the findings. Coma, seizures and prolonged acidosis were poor prognostic signs. The estimated amount of consumed methanol and the rapidity of the appearance of signs of toxicity following methanol ingestion did not seem to influence the outcome of poisoning. The most commonly observed clinical syndromes were: acute metabolic acidosis, severe visual impairment and acute pancreatitis. Four died within 72 hours after admission to the hospital. All had severe metabolic acidosis and visual impairment and three pancreatitis. Of 24 who recovered, 16 showed no residual complications, six had bi-lateral visual impairment and had difficulty in speech as well as visual impairment.