Registration Dossier
Registration Dossier
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EC number: 205-487-5 | CAS number: 141-52-6
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: basic data given
Data source
Reference
- Reference Type:
- publication
- Title:
- Critical Data Evaluation for MAK Values and Classification of Carcinogens.
- Author:
- Greim, H.
- Year:
- 1 999
- Bibliographic source:
- Occupational Toxicants 12, 128 - 165 (Wiley)
Materials and methods
Test material
- Reference substance name:
- Ethanol
- EC Number:
- 200-578-6
- EC Name:
- Ethanol
- Cas Number:
- 64-17-5
- Molecular formula:
- C2H6O
- IUPAC Name:
- ethanol
- Details on test material:
- test substance: ethanol
Constituent 1
Results and discussion
Any other information on results incl. tables
The toxicological assessment bases mainly on experiences in humans and the careful evaluation of the eliminination rates in humans. In the western caucasian race the elimination rate from the blood after the uptake of amounts leading to ADH saturation are 0.1 - 0.15 mg/ml per hour. This means that about 5-10 g of ethanol are eliminated from the body within 1 hour. In order to take into account also ADH-deficient persons this number is reduced to 1 g per person and hour. An uptake of 1 g per person and hour is about equivalent to the German OEL of 960 mg/m3 (500 ppm). At this level the obtained blood concentrations do not deviate from what is produced endogeneously. I has also been shown that 500 ppm are not irritating to eyes and mucous membranes and thus OEL derived from systemic investigations protects also from local toxicity.
Applicant's summary and conclusion
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