Registration Dossier
Registration Dossier
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EC number: 209-952-3 | CAS number: 598-78-7
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1983
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Endpoint only value. The document is insufficient for assessment
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 983
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Deviations:
- not specified
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Sodium 2-chloropropionate
- EC Number:
- 241-067-8
- EC Name:
- Sodium 2-chloropropionate
- Cas Number:
- 16987-02-3
- Molecular formula:
- C3H5ClO2.Na
- IUPAC Name:
- sodium 2-chloropropanoate
- Details on test material:
- The test was conducted with the sodium salt of 2-chloropropionic acid, CAS number 16987-02-3, EC number 241-067-8
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Details on mammalian cell type (if applicable):
- No additional data presented
- Additional strain / cell type characteristics:
- not specified
- Metabolic activation:
- with and without
- Test concentrations with justification for top dose:
- 20 µg to 500 µg per plate
- Vehicle / solvent:
- Not available
Controls
- Untreated negative controls:
- not specified
- Negative solvent / vehicle controls:
- not specified
- True negative controls:
- not specified
- Positive controls:
- not specified
- Positive control substance:
- not specified
- Details on test system and experimental conditions:
- Standard plate and preincubation test
- Evaluation criteria:
- No additional data presented
- Statistics:
- No additional data presented
Results and discussion
Test results
- Key result
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- True negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Additional information on results:
- No additional data presented
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results:
negative
A negative result was obtained in an Ames test conducted on the sodium salt of 2-chloropropionic acid. - Executive summary:
The sodium salt of 2-chloropropionic acid was subject to an Ames test according to OECD guideline 471. The test was carried out according to GLP. A negative result was obtained both with and without metabolic activation.
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