Registration Dossier
Registration Dossier
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EC number: 209-952-3 | CAS number: 598-78-7
Endpoint summary
Administrative data
Description of key information
Additional information
A key study is presented performed according to OECD 301B, CO2 evolution test (5.2.1, 001). This test was conducted to GLP and the reference substance was sodium acetate. 2-Chloropropionic acid gave a positive result (> 60% degradation relative to the theoretical carbon dioxide value) with a maximum of 99% degradation being recorded on day 29. Therefore, the final conclusion is that 2-chloropropionic acid is readily biodegradable in an aerobic aqueous environment.
In addition, four studies are included from the IUCLID 4 dossier as supporting data. These studies include a BOD5/COD measurement which indicates 77% biodegradation after 30 days (43% after 5 days) , a study conducted according to the German standard DIN 38409, part 51 which indicates 100% biodegradation (although the inoculum utilised was adapted activated sludge) and a bioelimination study akin to the Zahn Wellens test where 98% elimination is reported after 28 days.[5.2.1, 002]
A research publication is included where information is summarised on the understanding as to the biodegradation of chlorinated compounds in the environment. Certain microorganisms capable of synthesising dehalogenase are reported to utilise 2 -chloropropionic acid in order to do this.
(Biodegradation of Halogenated Organic Compounds, G. R Chaudhry & S. Chapalamadugu, Microbiological Reviews, 1991, pages 59-790), [5.2.1, 003].
A second research publication utilises two putative dehalogenases from Pseudenomas sp. strain S3. These enzymes efficiently catalyse the dehalogenation of short chain haloacetates, making them useful for the degradation of 2-Chloropropionic acid.
(Degradation of D,L-2-Chloropropionic Acid by Bacterial Dehalogenases that shows Stereospecificity and its Partial Enzymatic Characteristics S. Thasif, S. Hamdan and F. Huyop, Biotechnology, 8(2) : 264-269, 2009) [5.2.1, 004]
All studies reported add to the weight of evidence that 2 -chloropropionic acid is readily biodegradable.
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