Registration Dossier
Registration Dossier
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EC number: 209-952-3 | CAS number: 598-78-7
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Remarks:
- in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1986
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Source is peer reviewed
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 1 980
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- No additional information on the guideline followed or the method employed is given
- GLP compliance:
- not specified
- Type of study:
- not specified
- Justification for non-LLNA method:
- Study was conducted prior to the introduction of the LLNA.
Test material
- Reference substance name:
- 2-chloropropionic acid
- EC Number:
- 209-952-3
- EC Name:
- 2-chloropropionic acid
- Cas Number:
- 598-78-7
- Molecular formula:
- C3H5ClO2
- IUPAC Name:
- 2-chloropropanoic acid
- Details on test material:
- No additional data
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals and environmental conditions:
- No data
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Vehicle:
- no data
- Concentration / amount:
- No data
Challengeopen allclose all
- Vehicle:
- no data
- Concentration / amount:
- No data
- No. of animals per dose:
- No data
- Details on study design:
- No data
- Challenge controls:
- No data
- Positive control substance(s):
- not specified
Results and discussion
- Positive control results:
- No data
In vivo (non-LLNA)
Results
- Reading:
- other: Not sensitising
- Clinical observations:
- Not sensitising
- Remarks on result:
- other: Reading: other: Not sensitising. Clinical observations: Not sensitising.
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Interpretation of results:
- other: not sensitising
- Conclusions:
- The substance failed to produce a positive result in guinea pigs in a sensitisation test and is therefore considered to be non-sensitising.
- Executive summary:
The substance is reported to have been subjected to a sensitisation test in guinea pigs. No information on the guideline followed or the method employed is given.
The substance failed to give a positive result in the sensitisation test and is therefore considered to be non-sensitising to the skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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