Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 230-589-1 | CAS number: 7209-38-3
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- Not reported
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: BASF Test
- GLP compliance:
- no
Test material
- Reference substance name:
- N,N'-bis(3-aminopropyl)piperazine
- EC Number:
- 230-589-1
- EC Name:
- N,N'-bis(3-aminopropyl)piperazine
- Cas Number:
- 7209-38-3
- Molecular formula:
- C10H24N4
- IUPAC Name:
- 3-[4-(3-aminopropyl)piperazin-1-yl]propan-1-amine
- Test material form:
- liquid
- Details on test material:
- - name (as stated in the report): N,N'-Bis-aminopropyl-piperazin
- chemical name: 1,4-Bis-(aminopropyl)-piperazin
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- No information
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Duration of treatment / exposure:
- 1st experiment: 3 min
2nd experiment: 1 h - Observation period:
- 3 min or 1 h, 1 d, 2 d and 8 d after the exposure
- Number of animals:
- 3 min: 2 rabbits
1h: 4 rabbits - Details on study design:
- No further details
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Remarks:
- 1st experiment
- Basis:
- mean
- Time point:
- other: 3 min
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Remarks:
- 1st experiment
- Basis:
- mean
- Time point:
- other: 3 min
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- erythema score
- Remarks:
- 1st experiment
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 2
- Irritation parameter:
- edema score
- Remarks:
- 1st experiment
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 0.5
- Max. score:
- 1
- Irritation parameter:
- erythema score
- Remarks:
- 1st experiment
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 2
- Max. score:
- 2
- Irritation parameter:
- edema score
- Remarks:
- 1st experiment
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 2
- Max. score:
- 2
- Irritation parameter:
- erythema score
- Remarks:
- 1st experiment
- Basis:
- mean
- Time point:
- other: 8 d
- Score:
- 0.5
- Max. score:
- 1
- Irritation parameter:
- edema score
- Remarks:
- 1st experiment
- Basis:
- mean
- Time point:
- other: 8 d
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- erythema score
- Remarks:
- 2nd experiment
- Basis:
- mean
- Time point:
- other: 1 h
- Score:
- 2.5
- Max. score:
- 3
- Irritation parameter:
- edema score
- Remarks:
- 2nd experiment
- Basis:
- mean
- Time point:
- other: 1 h
- Score:
- 2
- Max. score:
- 2
- Irritation parameter:
- erythema score
- Remarks:
- 2nd experiment
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 3.5
- Max. score:
- 4
- Irritation parameter:
- edema score
- Remarks:
- 2nd experiment
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 2
- Max. score:
- 2
- Irritation parameter:
- erythema score
- Remarks:
- 2nd experiment
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 3.5
- Max. score:
- 4
- Irritation parameter:
- edema score
- Remarks:
- 2nd experiment
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 2
- Max. score:
- 2
- Irritation parameter:
- erythema score
- Remarks:
- 2nd experiment
- Basis:
- mean
- Time point:
- other: 8 d
- Score:
- 3.5
- Max. score:
- 4
- Irritation parameter:
- edema score
- Remarks:
- 2nd experiment
- Basis:
- mean
- Time point:
- other: 8 d
- Score:
- 1.5
- Max. score:
- 2
- Irritant / corrosive response data:
- skin corrosion was observed after treatment with test substance for 1 h
Any other information on results incl. tables
1st experiment:
| rabbit # | 3 min | 1 day | 2 days | 8 days | ||||||
| erythema | edema | erythema | edema | erythema | edema | erythema | edema | |||
| 1 | 0 | 0 | 0 | 0 | 2 | 2 | 0 sc | 0 | ||
| 2 | 0 | 0 | 2 | 1 | 2 wex | 2 wex | 1 sc | 0 | ||
2nd experiment:
| rabbit # | 1 hour | 1 day | 2 days | 8 days | ||||||
| erythema | edema | erythema | edema | erythema | edema | erythema | edema | |||
| 1 | 2 ex | 2 ex | 3 sn ex | 2 ex | 3 sn ex | 2 ex | 2 sn ex sc | 2 ex | ||
| 2 | 2 ex | 2 ex | 3 sn ex | 2 ex | 3 sn ex | 2 ex | 4 pn | 2 ex | ||
3 |
3 sn ex |
2 ex |
4 pn |
2 ex |
4 pn |
2 ex |
4 ln |
1 |
||
4 |
3 sn ex |
2 ex |
4 pn |
2 ex |
4 pn |
2 ex |
4 pn |
1 |
||
sn: spotty necrotic
ex: extending
wex: widely extending
sc: scaling
pn: parchment-like necrosis
ln: leathery necrosis
Applicant's summary and conclusion
- Interpretation of results:
- Category 1B (corrosive) based on GHS criteria
- Conclusions:
- Skin corrosive (Category 1B) was observed.
- Executive summary:
In a primary skin irritation/corrosion study, two rabbits were exposed to N,N'-bis(3 -aminopropyl)piperazine for 3 min and four rabbits were exposed for 1h. Observations were made 1 h, 24 h, 48 h and 8 d after exposure. While only mild irritation was observed after 3 min exposure, skin corrosion was observed after 1 h of exposure.
Based on these results:
- according to the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) of the United Nations, N,N'-bis(3 -aminopropyl)piperazine should be classified as: Skin corrosive (Category 1B).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
