Registration Dossier
Registration Dossier
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EC number: 230-589-1 | CAS number: 7209-38-3
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- February 1979 - January 1980
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Inhalation-risk test (IRT), method published: H.F. Smyth et al.: Am. Ind. Hyg. Ass. J. 23, 95 - 107 (1962)
Inhalation of an atmosphere which was enriched with the substance. The athmosphere was created by flowing 200 l air / h through a layer of the substance (height 5 cm, T = 20 °C). - GLP compliance:
- no
Test material
- Reference substance name:
- N,N'-bis(3-aminopropyl)piperazine
- EC Number:
- 230-589-1
- EC Name:
- N,N'-bis(3-aminopropyl)piperazine
- Cas Number:
- 7209-38-3
- Molecular formula:
- C10H24N4
- IUPAC Name:
- 3-[4-(3-aminopropyl)piperazin-1-yl]propan-1-amine
- Test material form:
- liquid
- Details on test material:
- - name (as stated in the report): N,N'-Bis-aminopropyl-piperazin
- chemical name: 1,4-Bis-(aminopropyl)-piperazin
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- air
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 7 h
- No. of animals per sex per dose:
- 12
- Control animals:
- no
Results and discussion
- Mortality:
- no mortalities
- Clinical signs:
- other: shaggy fur, rapid breathing, gasping respiration
- Other findings:
- respiratory irritation
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- After 7 h of exposure with substance-enriched atmosphere, no animal died. Respiratory irritation was observed. The test is not sufficient to make conclusion regarding the acute inhalation toxicity, because the concentration of the test substance was not evaluated.
- Executive summary:
An Inhalation-risk test (IRT) was performed as follows. Inhalation of an atmosphere which was enriched with the substance. The athmosphere was created by flowing 200 l air / h through a layer of the substance (height 5 cm, T = 20 °C). After 7 h of exposure, no animal died (12 rats). Respiratory irritation was observed. The test is not sufficient to make conclusion regarding the acute inhalation toxicity, because the concentration of the test substance was not evaluated..
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