Registration Dossier
Registration Dossier
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EC number: 224-030-0 | CAS number: 4170-30-3
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Description of key information
Intraperitoneal administration of crotonaldehyde to male mice resulted in decreased fertiliy indices and changes in sperm head morphology.
Effect on fertility: via oral route
- Dose descriptor:
- NOAEL
- 10 mg/kg bw/day
Additional information
one generation study in male and female F344 rats resulted in no effects to fertility or offspring at the highest dose tested (10 mg/kg bw oral gavage). No LOAEL was identified. No effects on parental or offspring. no fertility or histopathological effects.
Short description of key information:
one generation study in male and female F344 rats resulted in no effects to fertility or offspring at the highest dose tested (10 mg/kg bw oral gavage)
Effects on developmental toxicity
Description of key information
no data
Toxicity to reproduction: other studies
Additional information
Upon non-physiologically relevant administration (IP) effects on fertility were demonstrated when male mice were administered 8, 16 or 32 ul/kg bw crotonaldhyde for 5 consecutive days then mated with females. One time IP adminsitration resulted in sperm head abnormalities at 16 adn 32 ul/kg bw at 3 weeks and at 32 ul/kg bw at 5 weeks. In conclusion, no reproductive effects based on physiologically relevant routes of administration.
Justification for classification or non-classification
According to criteria in regulation No 1272/2008, classification is not warrented.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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