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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Acute oral LD50 rats:  174 mg/kg
Acute dermal LD50 in guinea pigs:  26 mg/kg
Acute inhalation LC50 in rats (4 hour):  120 ppm (336 mg/m3)

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
LD50
Value:
174 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Dose descriptor:
LC50
Value:
336 mg/m³ air

Acute toxicity: via dermal route

Endpoint conclusion
Dose descriptor:
LD50
Value:
26 mg/kg bw

Additional information

For acute oral toxicity in rats best data available (Union Carbide, 1942) was chosen and the oral LD50 for male and female rats upon oral gavage = 174 mg/kg.

For acute dermal toxicity, only data in guinea pigs is available (Smyth and Carpenter, 1944). Available data demonstrates that crotonaldehde is toxic upon dermal application (2 -24 hour application). Good agreement in available studies for 4 day exposure to crotonaldehyde (c.a. 25 mg/kg and 30 mg/kg from different publications). The dermal application of crotonaldehyde to guinea pig resulted in an LD50 of 26 mg/kg. No reliable data was identified in other species.

For acute inhalation toxicity, the best available data is Rinehart (1967). The study provides data from 10 min to 4 hour exposure times in rats. There are some analytical issues (difference between analytical and nominal values) but the data and dose response are consistent. Also, studies in mouse, rat and human showed that crotonaldehyde is a strong respiratory irritant. Results suggest that rat is the most sentitive species. LC50 value for 4 hour of exposure (within 24 hr) was 120 ppm (336 mg/m3), nevertheless, a ceiling threshold level value has been established at 0.3 ppm (0.86 mg/m3) for occupational exposure to minimize the potential for rapid irritation to the respiratory tract (and eyes).

Justification for classification or non-classification

According to criteria in Regulation (EC) No. 1272/2008, as well as requirements in Annex VI thereof, and based on the observed LD50 values (acute oral, dermal and inhalation), the susbtance has to be classified as follows:

Oral - acute toxicity Cat 3

Dermal - acute toxicity Cat 1

Inhalation - acute toxicity Cat 2

STOT - single exposure Cat 3