Registration Dossier
Registration Dossier
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EC number: 810-201-2 | CAS number: 1050477-27-4
Melting point / freezing point
Administrative data
Link to relevant study record(s)
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 2016
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- thermal analysis
- Remarks:
- Differential Thermal Analysis (DTA)
- Melting / freezing pt.:
- 224.4 °C
- Remarks on result:
- other: mean of four determinations (No pressure reported)
- Conclusions:
- The melting point of Rac-Amido-TH-naphthyridin is determined as 224.4 °C. No pressure was reported.
- Executive summary:
According to EU Method A. 1 a differential thermoanalysis method (DTA) was used to determine the melting point of Rac-Amido-TH-naphthyridin. The sample is closed up in a crucible made of aluminium and heated up in a DTA/DSC system (heating rate 1 K/min). In comparison with an inert sample (empty crucible) the temperature difference and the heat effect are recorded. The melting curve of the sample is a steep endothermic signal.The melting temperature lies at 224.4 °C (mean of four determinations, twice in an open and twice in a closed crucible). A second heating could not reproduce the melting point which indicates a chemical transformation of the test item. This assumption is supported by the orange-brownish melt in the crucible. This effect is demonstrated by two successive measurements (closed crucible). The sample was heated up to 250 °C, cooled down to 220 °C and heated up again.
Reference
A second heating could not reproduce the melting point which indicates a chemical transformation of the test item. This assumption is supported by the orange-brownish melt in the crucible.
This effect is demonstrated by two successive measurements (closed crucible). The sample was heated up to 250 °C, cooled down to 220 °C and heated up again.
The result was a mean of four determinations, twice in an open and twice in a closed crucible.
Description of key information
The melting point for Rac-Amido-TH-naphthyridin is determined as 224.4 °C. No pressure was reported.
Key value for chemical safety assessment
- Melting / freezing point at 101 325 Pa:
- 224.4 °C
Additional information
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