Registration Dossier
Registration Dossier
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EC number: 222-981-6 | CAS number: 3687-46-5
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
The potential for bioaccumulation of the category members of the Long Chain Alcohol Esters in animal tissue is assumed to be low.
Key value for chemical safety assessment
Additional information
The BCF for the Long Chain Alcohol Esters was calculated to be 3.162 – 28.88 L/kg wet weight (BCFBAF v3.00, regression based estimate) which indicates that accumulation in organisms is possible. When including biotransformation rate constants the BCF was 0.89 – 0.93 L/kg (Arnot-Gobas estimate, including biotransformation, upper trophic). If taken up into fish, the category members of the Long Chain Alcohol Esters are expected to be rapidly metabolised and excreted. The metabolism of Long Chain Alcohol Esters is well known, which is comparable to other dietary fats. Higher molecular weight aliphatic esters are readily hydrolysed to the corresponding alcohol and acid and then generally oxidised to CO2 and H2O via the breakdown into two-carbon fragments, which are used by the body for both energy supply and synthesis. Long Chain Alcohol Esters are hydrolysed to free fatty acids for absorption from the intestine into the blood by lipase enzymes and bile salts during digestion. Once formed, the free fatty acids are metabolised by known oxidative processes (e.g. citric acid cycle) or they are reconstituted into glyceride esters (e.g. mono-, di- or triglycerides). Triglycerides play an important role as an energy reserve. Mono- and diglycerides have an amphiphilic character and are found in biological membranes or act as emulsifiers.
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