Registration Dossier
Registration Dossier
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EC number: 214-688-7 | CAS number: 1185-81-5
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Testing conformed to Good Laboratory Practice standards (OECD 1998, EPA CFR 792), Daphnia sp., Acute Immobilization Test and Reproduction Test (OECD Method 202) guidelines.
Prior to conducting the definitive toxicity test, a range finding toxicity test was conducted to determine the product concentrations to be used in the acute definitive testing. Results of the acute range finding test indicated a 48 hour EC50 value of 1.345 mg/L.
A Definitive Test was conducted resulting in a 48 hour EC50 (reported as EL50) value of 1.40 mg/L, based on nominal concentrations of the Water Accommodated Fraction (WAF) of the test material.
Measured concentrations, using concentration of Tin as a surrogate, yielded an EC50 of 0.023 mg/L as Tin. Assuming that the ratio of Tin remains the same in the Water Accommodated Fraction as in the product (18.1%), the resultant EC50 in terms of the test material concentration is 0.11 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.11 mg/L
Additional information
- In the key study (Rasnake et al, 2010) for the acute toxicity to Daphnia magna, the study was conducted according to the OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test) and GLP.
This study is presented as the key information as the reliability rating for this study is 1, according to the criteria of Klimisch, 1997. This is the most recent and robust study available and has been used for classification purposes.
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