Registration Dossier
Registration Dossier
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EC number: 214-688-7 | CAS number: 1185-81-5
Partition coefficient
Administrative data
Link to relevant study record(s)
Description of key information
The partition coefficient of the test item has been determined to be 1.27 x 10ˆ3 at 22.0 ± 0.5°C, log10 Pow 3.11, using the shake-flask method, designed to be compatible with Method A8 Partition Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 107 of the OECD Guidelines for Testing of Chemicals, 27 July 1995. However, it is critical to note that there was a failure of correlation between the water solubility data and the concentrations of test item detected in the aqueous phase which indicated a potential systematic error/interference in the definitive test.
As stated previously, although a chromatographic peak was resolved by the analytical method, even on the application of a mass selective detector, the analytical method may not have been substance specific to the test item. Organotin compounds, due to thermal instability, do not result in a detectable parent mass ion on analysis. The ion monitored analytically was that of a tin adduct with tropolone (introduced as a mobile phase additive). Therefore analytical values for the aqueous phase may have been subject to interference from the presence of water soluble tin containing impurities and/or hydrolysis products which would partition from the organic phase into the aqueous phase leading to the systematic underestimation of the partition coefficient of the parent test item.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 3.11
- at the temperature of:
- 22 °C
Additional information
A reliability rating of 1 was assigned to the key study according to the criteria of Klimisch, 1997 as the study was conducted in accordance with recognised guidelines and GLP.
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