Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 215-158-8 | CAS number: 1308-14-1
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Information from a peer reviewed Assessment Report, original study not available
Data source
Reference
- Reference Type:
- other: Peer reviewed assessment report
- Title:
- Unnamed
- Year:
- 2 009
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Chromium (III) oxide
- EC Number:
- 215-160-9
- EC Name:
- Chromium (III) oxide
- Cas Number:
- 1308-38-9
- Reference substance name:
- Chromium(III) oxide
- IUPAC Name:
- Chromium(III) oxide
- Reference substance name:
- Chromium(III) oxide
- IUPAC Name:
- Chromium(III) oxide
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- rabbit
Test system
- Vehicle:
- water
- Amount / concentration applied:
- 500 mg
Results and discussion
Any other information on results incl. tables
500 mg of chromium oxide (moistened with water) showed no skin irritation effects with rabbits.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: not specified
- Conclusions:
- No irritation/corrosion effects in rabbits could be detected after applying 500 mg of chromium(III) oxide dissolved in water.
- Executive summary:
In a acute dermal irritation study (according to OECD Guideline 404, Acute Dermal Irritation/Corrosion) rabbits had been exposed to chromium(III) oxide (moistened with water). In this study chromium(III) oxide at concentrations of 500 mg was not a dermal irritant.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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