esterification product of 2-hydroxypropane-1,3-diyl-bis(2-methylprop-2-enoate) and 3-hydroxypropane-1,2-diyl-bis(2-methylprop-2-enoate) and diphosphorus pentoxide

Water solubility

Administrative data

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

25 October - 13 November 2001

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Guideline study under GLP

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2002

Report date:

2002

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Test material

Test material information

Constituent 1

Reference substance name:

1224866-76-5

Cas Number:

1224866-76-5

IUPAC Name:

1224866-76-5

Details on test material:

- Name of test material (as cited in study report): Glypho
- Substance type: pure active substance
- Physical state: liquid
- Stability under test conditions: Stable
- Storage condition of test material: Refrigeration at ca. 4°C
- Other: bottles not to be filled > 90%, oxygen inhibits polymerisation

Results and discussion

Water solubility

Water solubility:

63.2 g/L

Temp.:

20 °C

pH:

>= 1.25 - <= 1.3

Details on results:

std deviation ±5.3 g/L

RUTH: please select ≤ for pH (HI)

Any other information on results incl. tables

Table, Water solubility study information for the test substance
Solution number	1	2	3	4	5	6
Mass of test substance (g)	3.10	3.34	3.43	3.52	3.52	3.60
Added volume of water (mL)	25	25	25	25	25	25
Nominal loading rate (g/L)¹	124.0	133.6	137.2	140.8	140.8	144.0
Agitation time at 30 °C	72	72	48	48	24	24
pH of solution	1.26	1.25	1.26	1.28	1.26	1.30
Concentration analysed (mg/L)²	30.22	29.35	28.56	32.22	34.27	34.96
Concentration calculated (g/L)³	60.4	58.7	57.1	64.4	68.5	69.9
Average concentration				63.2 ± 5.3 g/L
1, Nominal loading rate = 1000 * mass of test substance (g)/added volume of water (mL) 2, Concentration analysed, Concentration quantified by peak area with reference to the calibration curve 3, Concentration calculated = 2000 (df) * concentration analysed

Applicant's summary and conclusion

Conclusions:

Interpretation of results (migrated information): very soluble (> 10000 mg/L)
The water solubility of CAS# 1224866-76-5 at 20 °C is 63.2 g/L, final pH 1.25-1.3 (OECD TG105)

Executive summary:

The water solubility of CAS# 1224866-76-5 was determined according to OECD TG105. The test substance was shaken for 24, 48 or 72 hours at 30 °C in duplicate and allowed to stand for 24 h at 20 C. The apparent water solubility did not increase over the course of the test and the measured solubility values differed by less than 15 %. The water solubility of CAS# 1224866-76-5 is 63.2 g/L, final pH 1.25-1.3.

This study was conducted according to internationally accepted test guidelines under GLP criteria. The result is considered reliable without restriction.