Registration Dossier
Registration Dossier
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EC number: 249-528-5 | CAS number: 29232-93-7
Immunotoxicity
Administrative data
Description of key information
Key value for chemical safety assessment
Effect on immunotoxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Effect on immunotoxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Effect on immunotoxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
A detailed review of parameters related to immune function has been conducted on the existing toxicity database for the test substance. Repeat-dose studies in rats, mice and dogs were reviewed for any treatment-related changes in a variety of indicators of potential immunotoxicity including leukocyte counts, lymphocyte counts, globulin concentration, macroscopic findings (lymph nodes, thymus, and spleen), organ weights (spleen, thymus and adrenals), and microscopic findings (bone marrow, lymph nodes, spleen, thymus and adrenals).
A thorough review of the toxicology database for the test substance has shown no evidence of adverse effects on the immune system in rats, mice or dogs. In addition, the test substance does not belong to a class of chemicals (e.g., the organotins, heavy metals, or halogenated aromatic hydrocarbons) that would be expected to be immunotoxic.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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