Registration Dossier
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EC number: 249-528-5 | CAS number: 29232-93-7
Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: OECD TG 105
- Qualifier:
- according to guideline
- Guideline:
- other: EU Method A.6
- GLP compliance:
- yes
- Key result
- Medium:
- other: n-heptane
- Solubility:
- 189 g/L
- Temp.:
- 20 °C
- Medium:
- other: xylene
- Solubility:
- > 200 g/L
- Temp.:
- 20 °C
- Medium:
- other: 1,2-dichloroethane
- Solubility:
- > 200 g/L
- Temp.:
- 20 °C
- Medium:
- methanol
- Solubility:
- > 200 g/L
- Temp.:
- 20 °C
- Medium:
- acetone
- Solubility:
- > 200 g/L
- Temp.:
- 20 °C
- Medium:
- ethyl acetate
- Solubility:
- > 200 g/L
- Temp.:
- 20 °C
- Test substance stable:
- yes
- Conclusions:
- The substance is highly soluble in commonly used organic solvents.
- Executive summary:
The solubility of the test substance has been determined in six organic solvents in a GLP-compliant study in accordance with OECD TG 105 and EU Method A.6. At 20 °C the solubility of the technical test substance was >200 g/L solution in xylene, 1,2-dichloroethane, methanol, acetone, ethyl acetate, and 189 g/L solution in n-heptane.
Reference
RESULTS
The solubility of technical test substance at 20 °C is > 250 g per kg solution (> 200 g per L solution) in all the solvents tested with the exception of n-heptane where it has a solubility of 249 g per kg (189 g per L solution). With the exception of n-heptane the test substance completely dissolved hence the solubility can be calculated to be > 250 g per kg solution. In the case of n-heptane the weight of test substance in the 500 µL aliquot was determined by gravimetry. Using the density of the solvent and the weight of the 500 µL aliquot it is possible to calculate results in alternative units.
Table 1 Solvent Solubility results
Solvent |
Solubility (g per kg solution) |
Solubility (g per L solution) |
Solubility (g per 100 cm3 solvent) |
n-heptane |
249 |
189 |
23 |
xylene |
>250 |
>200 |
>42 |
1,2-dichloroethane |
>250 |
>200 |
>29 |
methanol |
>250 |
>200 |
>26 |
acetone |
>250 |
>200 |
>30 |
ethyl acetate |
>250 |
>200 |
>26 |
Description of key information
The solubility of the technical test substance at 20 °C is >200 g /L in all the solvents tested with the exception of n-heptane in which the solubility is 189 g/L.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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