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REACH

Pirimiphos-methyl

EC number: 249-528-5 | CAS number: 29232-93-7

Life Cycle description
Uses advised against

Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information

Additional information

Overview of key values for environmental fate and pathways of the test substance

Endpoint	Key value for assessment	Comments
Phototransformation in air	Estimated DT50: 0.802 hours by hydroxyl radical oxidation	Calculation, Atkinson method
Hydrolysis	DT50: 117 days at 25˚C pH7 condition	EPA Subdivision N, section 161 -1 and EU Method C.7 guidelines
Phototransformation in water	DT50: 0.07 days at 25˚C in nature pond water	MAFF Agchem Test guideline 12 Nousan N and a proposal of new OECD Guideline
Biodegradation in water and sediment: simulation tests	DT50: 5.19 days at 20˚C in aerobic freshwater-sediment system	BBA Part IV 5-1
Biodegradation in soil	DT50: 8.3 days at 19˚C	No guideline followed
Bioaccumulation	BCF (whole fish): 1264	OECD TG 305
Adsorption/Desorption	Arithmetic mean Kfoc = 2356 L/kg	OECD TG 106

A number of metabolites were identified in the simulation studies on biodegradation in water/sediment and soil, as well as in the ADME studies. An overview is provided here to give guidance on the assignment of abbreviations used in the different study summaries.

	Metabolite assignment
IUPAC name	Kirkpatrick 1994	Arnold et al. 1976	Hand 1996	Adam 2005	Macpherson 1998
2-(diethylamino)-6-methylpyrimidin-4-ol	M1	M1	M1	M4	M4
2-(diethylamino)-6-methylpyrimidin-4-yl dimethyl phosphate	N/A	M2	N/A	N/A	N/A
2-(ethylamino)-6-methylpyrimidin-4-ol	N/A	M3	N/A	M7	M5
N,N-diethyl-4-methoxy-6-methylpyrimidin-2-amine	N/A	M4	N/A	N/A	N/A
O-[2-(ethylamino)-6-methylpyrimidin-4-yl] O,O-dimethyl phosphorothioate	N/A	M5	N/A	N/A	M2
O-(2-amino-6-methylpyrimidin-4-yl) O,O-dimethyl phosphorothioate	N/A	N/A	N/A	N/A	M3
2-amino-6-methylpyrimidin-4-ol	N/A	N/A	N/A	N/A	M6
O-[2-(ethylamino)-6-methylpyrimidin-4-yl] O-methyl hydrogen phosphorothioate	N/A	N/A	N/A	N/A	M7
O-[2-(diethylamino)-6-methylpyrimidin-4-yl] O-methyl hydrogen phosphorothioate	N/A	N/A	M2	N/A	M9
2-[ethyl(2-hydroxyethyl)amino]-6-methylpyrimidin-4-yl dimethyl phosphate	N/A	N/A	N/A	N/A	M10
O-{2-[ethyl(2-hydroxyethyl)amino]-6-methylpyrimidin-4-yl} O-methyl hydrogen phosphorothioate	N/A	N/A	N/A	N/A	M15
2-(ethylamino)-6-methylpyrimidin-4-yl dimethyl phosphate	N/A	N/A	N/A	N/A	M16
N,N-diethylguanidine	N/A	N/A	N/A	M5	N/A
N-(N,N,N'-triethylcarbamimidoyl)acetamide	N/A	N/A	N/A	M11a	N/A
N-ethylguanidine	N/A	N/A	N/A	M11b	N/A
2-(diethylamino)-5-methyl-4H-imidazol-4-ol	N/A	N/A	N/A	M12	N/A
	N/A: not applicable, i.e., not identified in the study

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