Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 482-200-1 | CAS number: -
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Version / remarks:
- Adopted: 17 July 1992
- Qualifier:
- according to guideline
- Guideline:
- other: Testing guidelines for Studies of Chemicals, Section 3-3, "Fish, acute toxicity test"
- Version / remarks:
- Notification No. 2018-12, issued by the National Institute of Environmental Research, Korea on April 09, 2018
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Lot No. 180705
Purity: 99.08%
Appearance: White crystal
Molecular Weight: 693.57 g/mol
Molecular Formula: C36H30N3O6P3
Storage condition: Room temperature - Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- Species: Zebrafish (Danio rerio)
Supplier: Environmental Toxicology Lab, HTRC
Size: 2-3 cm
Water temp.: 21-25 oC
Photo period: 16 hours/8hours (Light/Darkness)
D.O: at least 60% of the air saturation value - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Remarks on exposure duration:
- The temperature of test water was maintained between 21-25 oC and photoperiods were 16 hours of light and 8 hours of darkness, which was the same as breeding condition. Do.O conentration was upper 60%.
- Hardness:
- 49 mg/L as CaCO3
- Test temperature:
- 21.5 oC (min. 21.1 oC~max 22.1 oC
- pH:
- 7.84 (min. 7.55~max. 8.10)
- Dissolved oxygen:
- 7.95 mg/l (min. 7.32 mg/L~max. 8.57 mg/L)
- Nominal and measured concentrations:
- Nominal concentration: 100 mg/L
- Key result
- Duration:
- 24 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Key result
- Duration:
- 72 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Validity criteria fulfilled:
- yes
- Remarks:
- The mortality in the control did not exceed 10% at the end of the test.
- Conclusions:
- The 96 hours LL (Lethal Loading rate)50 value of Phenoxycycloposphazene to zebrafish (Danio rerio) was determined to be higher than 100.0 mg/L, and NOELR (No Observable Effect Loading Rate) was 100.0 mg/L. The LL50 and NOELR were based on nominal concentration.
- Executive summary:
The Fish, Acute Toxicity Test of Phenoxycycloposphazene was studied using zebrafish (Danio rerio) for 96 hours uder the semi-static system. The toxicity test was performed in control and 100.0 mg/L (nominal concentration) as a limit test. The results were obtained as follows:
Observation
time
LC501)
(mg/L)
95% Confidence Limits
(mg/L)
NOEC2)
(mg/L)
24 hours >100 - 100 48 hours >100 - 100 72 hours >100 - 100 96 hours >100 - 100 1) Median lethal concentration, based on nominal concentration of main ingredient input ratio
2) No Observed Effect Concentration
No abnormal behaviors were observed in any of the test fish exposed to control and treat group during the test. The mean of total length and body weight of the test fish were 2.53 ±
0.11 cm and 0.16 ± 0.05 g. The mean of PH was 7.84 (min. 7.55 ~ max. 8.10). The mean of Dissoved Oxygen concentration (DO) was 7.95 mg/L (min. 7.32 mg/L ~max. 8.57 mg/L) and the percent of air saturation value was 91.8% (min. 85.2% ~max. 98.7%). The mean of temperature was 21.5oC (min. 21.1oC ~max. 22.1oC).
The 96 hours LL (Lethal Loading rate)50 value of Phenoxycycloposphazene to zebrafish (Danio rerio) was determined to be higher than 100.0 mg/L, and NOELR (No Observable Effect Loading Rate) was 100.0 mg/L. The LL50 and NOELR were based on nominal concentration.
Reference
Description of key information
The 96 hours LL (Lethal Loading rate)50value of Phenoxycycloposphazene to zebrafish (Danio rerio) was determined to be higher than 100.0 mg/L, and NOELR (No Observable Effect Loading Rate) was 100.0 mg/L. The LL50and NOELR were based on nominal concentration.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- LC50
- Effect concentration:
- >= 100 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
