Piperidin-4-ol

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data from peer reviewed journal

Data source

Reference

Reference Type:

publication

Title:

Range-Finding Toxicity Data: List VI

Author:

Henry F. Smyth Jr., Charles P. Carpenter, Carrol S. Well, Urbano C. Pozzani & Jean A. Striegel

Year:

1962

Bibliographic source:

American Industrial Hygiene Association Journal, 1962, 23:2, 95-107

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

To assess the extent of ocular injury caused by 1-methyl piperazine in rabbits

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

1-methylpiperazine

EC Number:

203-639-5

EC Name:

1-methylpiperazine

Cas Number:

109-01-3

Molecular formula:

C5H12N2

IUPAC Name:

1-methylpiperazine

Test material form:

liquid

Details on test material:

Name of test material (as cited in study report): 1-methyl piperazine
Molecular formula : C5H12N2
Molecular weight : 100.1638 g/mol
Substance Type: Organic
Physical State: Liquid

Specific details on test material used for the study:

Name of test material (as cited in study report): 1-methyl piperazine
Molecular formula : C5H12N2
Molecular weight : 100.1638 g/mol
Substance Type: Organic
Physical State: Liquid

Test animals / tissue source

Species:

rabbit

Strain:

not specified

Details on test animals or tissues and environmental conditions:

no data

Test system

Vehicle:

unchanged (no vehicle)

Controls:

not specified

Amount / concentration applied:

no data

Duration of treatment / exposure:

no data

Observation period (in vivo):

no data

Number of animals or in vitro replicates:

no data

Details on study design:

TEST SITE
Area of exposure: eye
% coverage: No data
Type of wrap if used: no wrap used

REMOVAL OF TEST SUBSTANCE
Washing (if done): no data
Time after start of exposure: no data

SCORING SYSTEM:
Grade 1 indicates at most a very small area of necrosis resulting from 0.5 ml of undiluted chemical in the eye. Grade 5 indicates a so-called severe burn from 0.005 ml, and Grade 10 indicates a severe burn from 0.5 ml of a 1% solution in water or propylene glycol

Results and discussion

In vivo

Results

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

other: not mentioned

Score:

8

Max. score:

10

Reversibility:

not specified

Remarks on result:

probability of severe irritation

Irritant / corrosive response data:

Grade 8 score was reported from Grade 1-10

Applicant's summary and conclusion

Interpretation of results:

Category 2 (irritating to eyes) based on GHS criteria

Conclusions:

Primary Eye Irritation score for 1-methyl piperazine was Grade 8.
Based on the grade, 1-methyl piperazine was considered to be severely irritating to eyes.

Executive summary:

Acute toxicity studies were carried out to assess the toxicity of 1-methyl piperazine. Eye injury in rabbits was recorded in a 10- grade ordinal series and was based upon the degree of corneal necrosis that resulted from instillation of various volumes and concentrations of chemical.

Grade 1 indicates at most a very small area of necrosis resulting from 0.5 ml of undiluted chemical in the eye. Grade 5 indicates a so-called severe burn from 0.005 ml, and Grade 10 indicates a severe burn from 0.5 ml of a 1% solution in water or propylene glycol. Primary Eye Irritation score for 1-methyl piperazine was Grade 8. Based on the grade, 1-methyl piperazine was considered to be severely irritating to eyes.