Registration Dossier
Registration Dossier
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EC number: 226-373-1 | CAS number: 5382-16-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from Secondary source
Data source
Reference
- Reference Type:
- secondary source
- Title:
- SIDS Initial Assessment Profile CAS no 110-97-4
- Author:
- OECD SIDS
- Year:
- 2 009
- Bibliographic source:
- US/ICCA, SIAM 29, 20-22 October 2009
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- Acute oral toxicity study of Diisopropanolamine in rats
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- yes
Test material
- Reference substance name:
- Diisopropanolamine
- Cas Number:
- 110-97-4/
- Molecular formula:
- C6H15NO2
- IUPAC Name:
- Diisopropanolamine
- Details on test material:
- - Name of test material (as cited in study report): Diisopropanolamine
- Molecular formula (if other than submission substance): C6H15NO2
- Molecular weight (if other than submission substance): 133.189 g/mole
- Substance type: Organic
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Diisopropanolamine
- Molecular formula (if other than submission substance): C6H15NO2
- Molecular weight (if other than submission substance): 133.189 g/mole
- Substance type: Organic
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- not specified
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality observed
- Mortality:
- No mortality observed at 2000 mg/kg
- Clinical signs:
- other: not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- LD50 was considered to be > 2000 mg/kg when rats were treated with Diisopropanolamine orally.
- Executive summary:
In acute oral toxicity study,rats were treated with Diisopropanolaminein the concentration of 2000 mg/kg orally.50 % mortality observed at 2000 mg/kg.Therefore, LD50 was considered to be> 2000 mg/kgwhen rats were treated with Diisopropanolamine orally.
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