Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 231-959-5 | CAS number: 7782-50-5
Toxicological information
Toxicological Summary
Currently viewing:
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.75 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 2
- Dose descriptor starting point:
- NOAEC
- Value:
- 1.5 mg/m³
- AF for dose response relationship:
- 1
- Justification:
- Human exposure
- AF for differences in duration of exposure:
- 2
- Justification:
- The animal and human studies showed that there is no substantial difference in N(L) OAECs following acute, subacute and/or chronic exposure by inhalation. This is supported by the fact that the toxic effects of chlorine are considered to be a function of its concentration in air and not the duration of exposure.
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Human data
- AF for other interspecies differences:
- 1
- Justification:
- Human data
- AF for intraspecies differences:
- 1
- Justification:
- A study in hyper-responsive subjects showed no significant difference in sensitivity.
- AF for the quality of the whole database:
- 1
- Justification:
- All end-points covered.
- AF for remaining uncertainties:
- 1
- Justification:
- No remaining uncertainties.
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.5 mg/m³
- Most sensitive endpoint:
- irritation (respiratory tract)
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- other: EU IOELV
- Overall assessment factor (AF):
- 1
- Modified dose descriptor starting point:
- NOAEC
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.75 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 2
- Dose descriptor:
- NOAEC
- AF for dose response relationship:
- 1
- Justification:
- Human exposure
- AF for differences in duration of exposure:
- 2
- Justification:
- The animal and human studies showed that there is no substantial difference in N(L) OAECs following acute, subacute and/or chronic exposure by inhalation. This is supported by the fact that the toxic effects of chlorine are considered to be a function of its concentration in air and not the duration of exposure.
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Human data
- AF for other interspecies differences:
- 1
- Justification:
- Human data
- AF for intraspecies differences:
- 1
- Justification:
- A study in hyper-responsive subjects showed no significant difference in sensitivity.
- AF for the quality of the whole database:
- 1
- Justification:
- All end-points covered
- AF for remaining uncertainties:
- 1
- Justification:
- No remaining uncertainties
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.5 mg/m³
- Most sensitive endpoint:
- irritation (respiratory tract)
DNEL related information
- DNEL derivation method:
- other: EU IOELV
- Overall assessment factor (AF):
- 1
- Dose descriptor starting point:
- NOAEC
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
Acute/short term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- other toxicological threshold
- Value:
- 0.5 % in mixture (weight basis)
- Most sensitive endpoint:
- skin irritation/corrosion
DNEL related information
- Dose descriptor:
- other: NOAEL
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
- Dose descriptor starting point:
- other: NOAEL
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- high hazard (no threshold derived)
Additional information - workers
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.75 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 2
- Dose descriptor starting point:
- NOAEC
- Value:
- 1.5 mg/m³
- AF for dose response relationship:
- 1
- Justification:
- Human exposure
- AF for differences in duration of exposure:
- 2
- Justification:
- The animal and human studies showed that there is no substantial difference in N(L) OAECs following acute, subacute and/or chronic exposure by inhalation. This is supported by the fact that the toxic effects of chlorine are considered to be a function of its concentration in air and not the duration of exposure.
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Human data
- AF for other interspecies differences:
- 1
- Justification:
- Human data
- AF for intraspecies differences:
- 1
- Justification:
- A study in hyper-responsive subjects showed no significant difference in sensitivity.
- AF for the quality of the whole database:
- 1
- Justification:
- All end-points covered.
- AF for remaining uncertainties:
- 1
- Justification:
- No remaining uncertainties
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.5 mg/m³
- Most sensitive endpoint:
- irritation (respiratory tract)
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- other: EU IOELV
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.75 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 2
- Dose descriptor:
- NOAEC
- Value:
- 1.5 mg/m³
- AF for dose response relationship:
- 1
- Justification:
- Human data
- AF for differences in duration of exposure:
- 2
- Justification:
- The animal and human studies showed that there is no substantial difference in N(L) OAECs following acute, subacute and/or chronic exposure by inhalation. This is supported by the fact that the toxic effects of chlorine are considered to be a function of its concentration in air and not the duration of exposure.
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Human data
- AF for other interspecies differences:
- 1
- Justification:
- Human data
- AF for intraspecies differences:
- 1
- Justification:
- A study in hyper-responsive subjects showed no significant difference in sensitivity.
- AF for the quality of the whole database:
- 1
- Justification:
- All end-points covered
- AF for remaining uncertainties:
- 1
- Justification:
- No remaining uncertainties
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.5 mg/m³
- Most sensitive endpoint:
- irritation (respiratory tract)
DNEL related information
- DNEL derivation method:
- other: EU IOELV
- Overall assessment factor (AF):
- 1
- Dose descriptor starting point:
- NOAEC
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
Acute/short term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.5 % in mixture (weight basis)
- Most sensitive endpoint:
- skin irritation/corrosion
DNEL related information
- Overall assessment factor (AF):
- 1
- Dose descriptor:
- other: NOAEL
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.25 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 200
- Modified dose descriptor starting point:
- NOAEL
Acute/short term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- high hazard (no threshold derived)
Additional information - General Population
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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