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EC number: 265-150-3
CAS number: 64742-48-9
A complex combination of hydrocarbons obtained by treating a petroleum fraction with hydrogen in the presence of a catalyst. It consists of hydrocarbons having carbon numbers predominantly in the range of C6 through C13 and boiling in the range of approximately 65°C to 230°C (149°F to 446°F).
Unleaded gasoline samples API 91-01 and API PS-6 were
both administered via semi-occlusive patch for four
hours to two groups of 6 New Zealand White rabbits (one group per test
material) to assess dermal irritation. Dermal
responses were evaluated at 1, 24, 48, and 72h post-dosing and on Days
7, 10, and 14 according to the Draize method of scoring. Animals
administered API 91-01 exhibited moderate to severe erythema (grade 3)
at the 24h, 48h and 72h observation point. The erythema was fully
reversible within 14 days. In the same group, maximum edema was noted in
the 1st hour of observation and fluctuated with severity from slight
(grade 2, 24 h) to very slight and no edema (grade 0/1, day 7); all
animals were clear of edema by Day 14. Animals administered API PS-6
exhibited moderate erythema (grade 2) at the 24h, 48h, and 72 h
observation point. The erythema was fullly reversible within 14 days.
Maximum edema was observed 1h after removal of the patch and irritation
due to edema subsided and was clear by Day 14 of the observation period.
The mean erythema and edema scores for API 91-01 were 2.56 and 1.89,
respectively. The mean erythema and edema score for API PS-6 were
2.39 and 1.39, respectively. This finding warrants classification
of API 91-01 and API PS-6 as irritating under Regulation (EC) 1272/2008
on classification, labeling, and packaging of substances and mixtures
(CLP) and as an R38 skin irritant under the Directive 67/518/EEC for
dangerous substances and Directive 1999/45/EC for preparations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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