Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 265-150-3
CAS number: 64742-48-9
A complex combination of hydrocarbons obtained by treating a petroleum fraction with hydrogen in the presence of a catalyst. It consists of hydrocarbons having carbon numbers predominantly in the range of C6 through C13 and boiling in the range of approximately 65°C to 230°C (149°F to 446°F).
Gasoline exposure does not affect the immune system in experimental animals at levels up to 20000 mg/m3.
A number of authors have suggested that
exposure to hydrocarbons including gasoline could be a causal factor in
the development of end stage glomerular nephritis (Bierne and Brennan,
1972; Zimmerman et al., 1975; Finn et al., 1980; Kleinknecht et al.,
publications reported a greater percentage of exposure among patients
than controls. The
majority of these publications were summaries of case reports. A
subsequent review of the literature on this subject (Churchill et al.,
1983) concluded that there were serious methodological deficiencies in
most of the studies which limited their utility. Churchill
identified 4 major weaknesses; (1) the use of inappropriate control
groups; (2) the use of unblinded interviewers; (3) failure to consider
recall bias; and (4) failure to define a credible measure of hydrocarbon
noted that among the case reports suggesting a relationship between
"hydrocarbon" exposure and either Goodpasture's syndrome or
antiglomerular basement membrane disease, 4 involved exposure to
gasoline specifically (Sprecace, 1963; Heale et al., 1969; and D'Apice
et al., 1978). There
is one additional case reported in Zimmerman et al. (1975). One
of the 4 cases identified by Churchill was an 18 year old girl who had
sold gasoline for 2 weeks prior to the onset of symptoms (D'Apice, 1978). Among
the other 3, one washed cars (Heale et al., 1969), one was a cotton loom
turner (Heale, 1969), and one was an army clerk in an ordinance
warehouse (Sprecace, 1962). No
unusual exposures to gasoline are apparent in the documentation of any
of these cases. In
the case reported by Zimmerman et al. (1975), exposure was listed as to
"petroleum fuels" without further specification, and a renal biopsy was
not carried out to confirm the diagnosis.
An additional methodological weakness,
not identified by Churchill, was the lack of precision in the definition
of "hydrocarbon vapors." As
one example, Zimmerman et al. (1975) presented as a typical case a woman
employed in a dry cleaning facility, removing stains with carbon
tetrachloride, and Kleinknecht et al. (1980)
described two women who were exposed to a domestic solvent containing
sodium hydroxide, carboxymethyl
cellulose, nonylphenol, ethylene oxide, and butane. Some
of these substances are organic solvents, but only butane is a
is also reference to an animal model based on exposure to N'N'-diacetyl
benzidine that is neither a hydrocarbon nor a solvent. Thus
the human literature on this subject can best be described as
The possible relationship between
"hydrocarbon" exposure and end stage renal disease has been under
discussion for more than 30 years. There
are some case reports in humans, but, at least as these pertain to
gasoline, the number of cases is small and the relationship to gasoline
exposure is uncertain. The
experimental data in animals indicate that gasoline exposure does not
affect the immune system at levels up to 20,000 mg/m3(approximately
4000 ppm). Thus
it seems unlikely that there would be a relationship between exposure
and the development of autoimmune disease (ie, Goodpasture's disease)
and subsequent end stage renal disease except under conditions resulting
in frank pulmonary injury. In
principal, pulmonary injury could be associated with aspiration of
liquid gasoline into the lung but is unlikely to be caused by gasoline
vapor exposure except under conditions of extreme over-exposure at
levels exceeding the lower explosive limit.
For full citations to the references,
please see record 'Exposure related observations in
humans.0.14/immunotoxicity' in section 7.10.5.
Justification for selection of effect on immunotoxicity via inhalation route endpoint:
one of 2 studies on immunotoxicity of gasoline
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Siekdami užtikrinti, kad būtų patogu naudotis mūsų svetaine, jos tinklapiuose naudojame slapukus.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again