Registration Dossier
Registration Dossier
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EC number: 265-150-3 | CAS number: 64742-48-9 A complex combination of hydrocarbons obtained by treating a petroleum fraction with hydrogen in the presence of a catalyst. It consists of hydrocarbons having carbon numbers predominantly in the range of C6 through C13 and boiling in the range of approximately 65°C to 230°C (149°F to 446°F).
Neurotoxicity
Administrative data
Description of key information
Exposure to high levels of gasoline can produce acute central nervous system depression in humans and experimental animals.
Repeated exposure at lower, occupational levels of gasoline produced little evidence of chronic neurological effects in humans or in experimental animals.
Key value for chemical safety assessment
Effect on neurotoxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Effect on neurotoxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Effect on neurotoxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Both the human and animal data indicate that exposure to high levels of gasoline can produce acute central nervous system depression. There is also evidence from the clinical literature that repeated exposure to gasoline at very high levels, under abuse conditions, can produce more profound central nervous system effects. Less clear is the degree to which these effects may have been due to the lead additives as opposed to the hydrocarbon constituents. There is little evidence of chronic neurological effects in humans exposed repeatedly at lower, occupational levels. The animal data provide little experimental support for chronic neurological effects from either unleaded gasoline or naphtha blending stocks. Initial studies with wholly vaporized unleaded gasoline provided evidence of exacerbation of normal, age-related changes. However, subsequent studies with gasoline vapor and naphtha blending stocks had no clear or reproducible effects on motor activity, produced no functional changes, and did not induce histological changes in the nervous system. It is not known to what extent the differences between these studies, if real, were due to differing experimental conditions (i.e., subchronic versus chronic exposures) or specific constituents contributing to exposure (gasoline vapor versus wholly vaporized gasoline).
Justification for selection of effect on neurotoxicity via inhalation route endpoint:
one of 3 studies investigating the neurotoxicity of gasoline
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
